PMID: 1206725Nov 4, 1975Paper

The charge-state model of protein polymorphism in natural populations

Journal of Molecular Evolution
D R Marshall, A H Brown

Abstract

Routine electrophoretic surveys for genetic variation in natural populations depend primarily upon detecting differences in the net charge carried by a protein. We have calculated the proportion of base substitutions which would yield an electrophoretically detectable mutant protein, and the relative mutation rates among different chare classes, under a variety of simplifying assumptions. These calculations indicate that: (i) only 25 per cent of all single base mutations would lead to a charge change on a protein molecule. (ii) five distinct classes of electrophoretic variants can be generated from a specified protein by single base substitutions. (iii) the relative mutation rates differ markedly among the different charge classes which can be generated by single base substitutions. The estimates of the proportion of electrophoretically detectable mutant proteins and relative mutation rates among charge classes were relatively robust to changes in assumptions concerned with the kind and site of base substitutions and the amino acid composition of the protein.

References

May 3, 1972·Nature: New Biology·J M Smith
Dec 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·S C BernsteinJ L Hubby
May 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·R S SinghR C Lewontin
Jan 1, 1973·Annual Review of Genetics·R C Lewontin
Jan 1, 1973·Annual Review of Genetics·W M Fitch
Jan 1, 1972·Journal of Molecular Evolution·F Vogel
Nov 27, 1973·Journal of Molecular Evolution·M Nei, R Chakraborty
Feb 12, 1971·Nature·M Kimura, T Ohta
May 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·G B Johnson
May 16, 1969·Science·J L King, T H Jukes
Mar 1, 1965·Journal of Medical Genetics·E R HUEHNS, E M SHOOTER
Sep 1, 1973·Evolution; International Journal of Organic Evolution·T Preston Webster, John M Burns

❮ Previous
Next ❯

Citations

Dec 30, 1976·Journal of Molecular Evolution·M Nei, R Chakraborty
Jan 1, 1985·Journal of Molecular Evolution·D Graur
Jul 1, 1992·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·M C NavarroR N Incani
Nov 1, 1988·Annales De L'Institut Pasteur. Microbiology·P GoulletR Krishnamoorthy
Jun 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·T Mukai, C C Cockerham
Feb 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·T Maruyama, M Kimura
Jan 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·F J Ayala
Apr 2, 1998·Proceedings. Biological Sciences·F LiuD Charlesworth
Nov 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·J V Neel, E D Rothman
May 1, 1981·Annals of Human Biology·R Chakraborty
Aug 1, 1980·Theoretical Population Biology·C F Wehrhahn, C Gulizia
Oct 1, 1982·Analytical Biochemistry·T McLellan
Jul 1, 1978·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·A H Brown
Jul 1, 1980·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·B Blumenberg
Dec 1, 1979·The Japanese Journal of Surgery·Y YasudaS Matsumoto
Nov 3, 2009·Journal of Evolutionary Biology·V A Formica, E M Tuttle
Oct 1, 1980·Genetical Research·T F Cross, R D Ward
Nov 27, 2014·The Journal of Heredity·Robin S Waples
Jan 1, 1985·Evolution; International Journal of Organic Evolution·Michael C Wooten, Michael H Smith
May 1, 1987·Evolution; International Journal of Organic Evolution·Steph B J Menken
Dec 1, 1989·Evolution; International Journal of Organic Evolution·Jeffry B Mitton, William M Lewis
Jul 1, 1986·Infection and Immunity·O PorrasC Svanborg-Edén
Feb 21, 1986·Journal of Theoretical Biology·D Graur

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.