The chemical and biological background to alclofenac

Current Medical Research and Opinion
L F Wiggins

Abstract

The essential chemistry of alclofenac is described together with a resumé of the pharmacological and toxicological properties. Its metabolism is described and absorption and excretion commented upon. The unique character of the alclofenac molecule in relation to its active allyloxy group and its close conformational resemblance to L-tryptophan is emphasised. Particular note is made of the absence of gastro-intestinal irritation in the long-term studies in animals and in man.

References

Jul 1, 1973·The Journal of Pharmacy and Pharmacology·M Aylward, J Maddock
Aug 1, 1957·Proceedings of the Society for Experimental Biology and Medicine·E SIEGMUNDG LU

Citations

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