The chemical and biological potential of C ring modified triterpenoids

European Journal of Medicinal Chemistry
Bianka SiewertRené Csuk

Abstract

A convenient and elegant route has been developed to separate the natural regioisomers triterpenoids ursolic acid (UA) and oleanolic acid (OA) as well as derivatives thereof. Eleven unknown derivatives of OA were designed, synthesized, and their cytotoxicity was investigated. Further sixteen compounds were prepared to correlate all compounds in a SAR study. It could be shown that C-ring modifications of OA and UA have only a moderate influence onto the cytotoxic activity of the compounds but a significant impact onto the ability to trigger apoptosis in ovarian cancer cells (cell line A2780).

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Citations

Jul 16, 2015·European Journal of Medicinal Chemistry·Lucie HellerRené Csuk
Aug 2, 2015·Phytochemistry·Antonio MartinezAntonia Fernandez-Vivas
Jun 16, 2015·European Journal of Medicinal Chemistry·René CsukAhmed Al-Harrasi
Jan 27, 2015·European Journal of Medicinal Chemistry·Haijun ChenJia Zhou
Jan 27, 2015·European Journal of Medicinal Chemistry·René CsukAhmed Al-Harrasi
Jan 22, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Malwina ChudzikWojciech Król
Aug 25, 2019·Pathogens·Ines SifaouiIgnacio A Jiménez
Jan 13, 2015·Archiv der Pharmazie·Sven SommerwerkRené Csuk
Nov 10, 2015·Archiv der Pharmazie·Lucie HellerRené Csuk
Feb 23, 2021·The Journal of Organic Chemistry·Shlomo RozenSalvador Moncho
Jan 2, 2019·Bioorganic Chemistry·Anne LoescheRené Csuk
Jan 3, 2018·The Journal of Organic Chemistry·Desta Doro BumeThomas Lectka
Nov 10, 2018·Journal of the American Chemical Society·Matthieu J R RichterErick M Carreira

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