PMID: 9425665Jan 13, 1998Paper

The chemical-biological interface: developments in automated and miniaturised screening technology

Current Opinion in Biotechnology
J G Houston, M Banks

Abstract

The rapidly changing developments in genomics and combinatorial chemistry, generating new drug targets and large numbers of compounds, have caused a revolution in high-throughput screening technologies. Key to this revolution has been the introduction of robotics and automation, together with new biological assay technologies (e.g., homogeneous time resolved fluorescence). With ever increasing workloads, together with economic and logistical constraints, miniaturisation is rapidly becoming essential for the future of high-throughput screening and combinatorial chemistry. This is evident from the introduction of high-density microtitre plates, small volume liquid handling robots and associated detection technology.

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Citations

Feb 27, 1999·International Journal for Parasitology·M J Witty
Dec 22, 1999·Pharmacology & Therapeutics·D Joseph-McCarthy
Jan 16, 1999·Current Opinion in Biotechnology·J E González, P A Negulescu
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Dec 1, 2005·Analytical Chemistry·Richard J HodgsonJohn D Brennan

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