The chemical coding of 5-hydroxytryptamine containing enteroendocrine cells in the mouse gastrointestinal tract

Cell and Tissue Research
Yohan ReynaudJohn B Furness

Abstract

The majority of 5-HT (serotonin) in the body is contained in enteroendocrine cells of the gastrointestinal mucosa. From the time of their discovery over 80 years ago, the 5-HT-containing cells have been regarded as a class of cell that is distinct from enteroendocrine cells that contain peptide hormones. However, recent studies have cast doubt on the concept of there being distinct classes of enteroendocrine cells, each containing a single hormone or occasionally more than one hormone. Instead, data are rapidly accumulating that there are complex patterns of colocalisation of hormones that identify multiple subclasses of enteroendocrine cells. In the present work, multiple labelling immunohistochemistry is used to investigate patterns of colocalisation of 5-HT with enteric peptide hormones. Over 95 % of 5-HT cells in the duodenum also contained cholecystokinin and about 40 % of them also contained secretin. In the jejunum, about 75 % of 5-HT cells contained cholecystokinin but not secretin and 25 % contained 5-HT plus both cholecystokinin and secretin. Small proportions of 5-HT cells contained gastrin or somatostatin in the stomach, PYY or GLP-1 in the small intestine and GLP-1 or somatostatin in the large intestine. Rare or ve...Continue Reading

References

Jan 1, 1990·Annual Review of Nutrition·J E Morley
Sep 1, 1994·Developmental Dynamics : an Official Publication of the American Association of Anatomists·K D AikenK A Roth
Jun 18, 1998·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·P L AndrewsR A Joss
Sep 2, 2003·Gastroenterology·Bi-Guang Tuo, Jon I Isenberg
Dec 1, 1958·British Journal of Pharmacology and Chemotherapy·E BULBRING, A CREMA
Jan 19, 2005·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·J F Rehfeld
Feb 4, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·M KiddM C Champaneria
Apr 14, 2006·Alimentary Pharmacology & Therapeutics·G M MaweP L Moses
Aug 29, 2006·Autonomic Neuroscience : Basic & Clinical·Gareth J Sanger, Paul L R Andrews
Sep 12, 1902·The Journal of Physiology·W M Bayliss, E H Starling
Oct 25, 2006·Scandinavian Journal of Gastroenterology·Bengt SäfstenGunnar Flemström
Mar 31, 2007·American Journal of Physiology. Gastrointestinal and Liver Physiology·Milena BogunovicScott E Plevy
May 14, 2008·Gastroenterology·Mitchell L Schubert, David A Peura
Jun 17, 2008·American Journal of Physiology. Gastrointestinal and Liver Physiology·Mark KiddRoswitha Pfragner
May 22, 2009·Gastroenterology·Robin Spiller, Klara Garsed
Dec 1, 2011·Scandinavian Journal of Gastroenterology·Herbert F Helander, Lars Fändriks
Feb 22, 2012·Frontiers in Neuroscience·Joel C Bornstein
Sep 1, 2012·American Journal of Physiology. Gastrointestinal and Liver Physiology·Martin HaugenMark Kidd
Dec 12, 2012·Current Opinion in Endocrinology, Diabetes, and Obesity·Michael D Gershon
Feb 9, 2013·American Journal of Physiology. Gastrointestinal and Liver Physiology·Melina EllisJoel C Bornstein
Oct 9, 2013·The Journal of Physiology·Ravinarayan RaghupathiDamien J Keating
Jan 21, 2014·Cell and Tissue Research·Hyun-Jung ChoJohn B Furness
Jan 1, 2015·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Christopher S ReigstadPurna C Kashyap
Aug 1, 2015·The Journal of Physiology·Terence K Smith, Michael D Gershon
Aug 1, 2015·The Journal of Physiology·Nick J SpencerDamien J Keating
Oct 8, 2015·Annual Review of Physiology·Fiona M Gribble, Frank Reimann

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Citations

Mar 3, 2017·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·A M MartinD J Keating
Mar 23, 2017·Endocrinology·Alyce M MartinDamien J Keating
May 10, 2017·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·S DiwakarlaJ B Furness
Sep 4, 2019·Cell and Tissue Research·Therese E Fazio ColesJohn B Furness
Aug 15, 2019·Cell and Tissue Research·Hongxia WangJohn R Grider
Jan 29, 2020·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Shanti DiwakarlaJohn B Furness
Jul 25, 2018·Proceedings of the National Academy of Sciences of the United States of America·Constanza AlcainoArthur Beyder
Feb 7, 2021·Cell and Tissue Research·Hirofumi KuramotoJohn B Furness
Apr 3, 2021·Frontiers in Endocrinology·Bilal Haider ShamsiXue Qun Chen
Jun 8, 2021·Histochemistry and Cell Biology·Douglas J Taatjes, Jürgen Roth
Jun 21, 2021·Archives of Toxicology·M Carmen LouzaoLuis M Botana
Jul 24, 2021·Molecular Medicine Reports·Irene Alexandra SpiridonIrina Draga Căruntu
Aug 14, 2021·Frontiers in Pharmacology·Qi ZhaoYu-Ping Tang

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