Nov 25, 2003

The chemical form of selenium affects insulinomimetic properties of the trace element: investigations in type II diabetic dbdb mice

The Journal of Nutritional Biochemistry
Andreas S MuellerJohannes Rafael


The objective of the present study was to investigate the effects of oral selenate application in comparison to selenium deficiency and selenite treatment on the development of the diabetic status (glucose tolerance, insulin resistance and activities of glycolytic and gluconeogenic marker enzymes) in dbdb mice, representing a type II diabetic animal model. Therefore 21 adult male dbdb mice were assigned to 3 experimental groups of 7 animals each and put on a selenium deficient diet (< 0.03 mg/kg diet) based on torula yeast. Group 0Se was kept on selenium deficiency for 10 weeks while the mice of the groups SeIV and SeVI were supplemented daily with 15% of their individual LD(50) of sodium selenite or sodium selenate in addition to the diet. After 10 weeks a distinct melioration of the diabetic status indicated by a corrected glucose tolerance and a lowered insulin resistance was measured in selenate treated mice (group SeVI) in comparison to their selenium deficient and selenite treated companions and to their initial status. Activities of the glycolytic marker enzymes hexokinase, phosphofructokinase and pyruvate kinase were increased 1.7 to 3-fold in liver and/or adipose tissue by selenate treatment as compared to mice on sele...Continue Reading

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Mentioned in this Paper

Metabolic Process, Cellular
Selenium Compounds, Inorganic
Diabetes Mellitus, Non-Insulin-Dependent
Glucose Metabolism Disorders
Insulin Sensitivity
Extravasation of Diagnostic and Therapeutic Materials
Fat Pad
Enzymes, antithrombotic

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