The chemical inhibitors of cellular death, PJ34 and Necrostatin-1, down-regulate IL-33 expression in liver

Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte
Muhammad I ArshadMichel Samson

Abstract

Interleukin-33 (IL-33), a cytokine belonging to the IL-1 family, is crucially involved in inflammatory pathologies including liver injury and linked to various modes of cell death. However, a link between IL-33 and necroptosis or programmed necrosis in liver pathology remains elusive. We aimed to investigate the regulation of IL-33 during necroptosis-associated liver injury. The possible regulation of IL-33 during liver injury by receptor-interacting protein kinase 1 (RIPK1) and poly(ADP-ribose) polymerase 1 (PARP-1) was investigated in mice in vivo and in hepatic stellate cells in vitro. The liver immunohistopathology, flow cytometry, serum transaminase measurement, ELISA, and qPCR-based cytokine measurement were carried out. By using a chemical approach, we showed that pretreatment of mice with Necrostatin-1 (Nec-1) (inhibitor of RIPK1) and/or PJ34 (inhibitor of PARP-1) significantly protected mice against concanavalin A (ConA) liver injury (aspartate amino-transferase (AST)/alanine amino-transferase (ALT)) associated with down-regulated hepatocyte-specific IL-33 expression. In contrast, the expression level of most systemic cytokines (except for IL-6) or activation of liver immune cells was not altered by chemical inhibitors...Continue Reading

References

Jul 1, 1992·The Journal of Clinical Investigation·G TiegsA Wendel
Oct 26, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·G KünstleA Wendel
May 3, 2000·Proceedings of the National Academy of Sciences of the United States of America·K TakedaK Okumura
Apr 24, 2003·Critical Reviews in Toxicology·Lutz W D WeberAndreas Stampfl
Jan 13, 2006·Nature Chemical Biology·Alexei DegterevJunying Yuan
Dec 23, 2006·Proceedings of the National Academy of Sciences of the United States of America·Virginie CarriereJean-Philippe Girard
Nov 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Shafaqat AliMichael U Martin
Apr 15, 2008·Nature Chemical Biology·Alexei DegterevJunying Yuan
Aug 1, 2008·Proceedings of the National Academy of Sciences of the United States of America·Kazuyoshi TakedaKo Okumura
Sep 6, 2008·The American Journal of Pathology·Hong-Min NiXiao-Ming Yin
Dec 17, 2008·Annals of the New York Academy of Sciences·Taro Kawai, Shizuo Akira
Feb 28, 2009·Proceedings of the National Academy of Sciences of the United States of America·Kai WangDavid J Galas
May 13, 2009·Journal of Cellular and Molecular Medicine·Katia Bourd-BoittinNathalie Théret
May 15, 2009·Proceedings of the National Academy of Sciences of the United States of America·Corinne Cayrol, Jean-Philippe Girard
May 15, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Elina Zorde-KhvalevskyHilla Giladi
May 26, 2009·The Journal of Biological Chemistry·Dominique Talabot-AyerGaby Palmer
Jun 11, 2009·Journal of Cellular and Molecular Medicine·Pierrick MarvieMichel Samson
Jun 30, 2009·Immunity·Alexander U LüthiSeamus J Martin
Jul 17, 2009·Immunity·Mohamed Lamkanfi, Vishva M Dixit
Jul 29, 2009·The Journal of Experimental Medicine·Naiara BerazaChristian Trautwein
Dec 29, 2009·Biochemical and Biophysical Research Communications·Shafaqat AliMichael Uwe Martin
Jul 14, 2010·Trends in Immunology·Charlotte SummersEdwin R Chilvers
Jul 29, 2010·Physiological Reviews·Harmeet MalhiGregory J Gores
Sep 9, 2010·Nature Reviews. Molecular Cell Biology·Peter VandenabeeleGuido Kroemer
Oct 14, 2010·Methods in Molecular Biology·Julien DianaAgnès Lehuen
Jan 12, 2011·The Journal of Membrane Biology·Vladimir JurisicMija Colic
Mar 23, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Timea CsakGyongyi Szabo
May 11, 2011·European Journal of Immunology·Muhammad I ArshadMichel Samson
Jun 28, 2011·Journal of Hepatology·Vladislav VolarevicMiodrag L Lukic
Aug 31, 2011·Proceedings of the National Academy of Sciences of the United States of America·Jennifer V LuCraig M Walsh
Sep 17, 2011·Nature·Claudia GüntherChristoph Becker
Nov 18, 2011·Nature Immunology·Jiahuai HanDuan-Wu Zhang
Dec 27, 2011·Immunity·Lorenzo Galluzzi, Guido Kroemer
Jan 19, 2012·World Journal of Gastroenterology : WJG·Hai-Xia WangJin Gao
Apr 26, 2012·Liver International : Official Journal of the International Association for the Study of the Liver·Muhammad I ArshadMichel Samson

❮ Previous
Next ❯

Citations

Mar 20, 2016·Clinical Therapeutics·Muhammad Imran ArshadMichel Samson
Nov 11, 2016·Cell Death & Disease·Aveline FilliolMichel Samson
Aug 8, 2015·American Journal of Physiology. Gastrointestinal and Liver Physiology·Muhammad Imran ArshadMichel Samson
Apr 25, 2020·Cells·Samantha SarcognatoMaria Guido
Sep 29, 2017·PloS One·Waqar K SaeedHyeon Tae Kang
May 4, 2017·Immunological Reviews·Wulf Tonnus, Andreas Linkermann
Dec 8, 2016·Cell Death Discovery·Lily DaraNeil Kaplowitz
Jul 29, 2017·American Journal of Physiology. Gastrointestinal and Liver Physiology·Aveline FilliolMichel Samson
Feb 28, 2020·American Journal of Respiratory and Critical Care Medicine·Jennifer SimpsonSimon Phipps
Jan 1, 2021·Microbial Pathogenesis·Hilal Ahmad KhanMuhammad Imran Arshad
Dec 24, 2020·International Journal of Molecular Sciences·Layla ShojaieLily Dara
Apr 26, 2021·Signal Transduction and Targeted Therapy·Yiyue GeJianyang Zeng
Dec 19, 2021·Cell Death & Disease·Takayuki KondoRajiv Jalan

❮ Previous
Next ❯

Related Concepts

Related Feeds