The chemical stability and sterility of sodium thiopental after preparation

Anesthesia and Analgesia
J L HawsD Jones

Abstract

Manufacturer's instructions recommend discarding unused portions of sodium thiopental 24 h after reconstitution. Heeding this recommendation may result in the disposal of a large proportion of prepared thiopental. Although thiopental is relatively inexpensive, the volume prepared by many anesthesia departments could make this waste significant. To address this possibility, we investigated the chemical stability and sterility of thiopental in pharmacy-prepared, prefilled syringes. Stock solutions of thiopental were mixed and drawn into syringes under sterile conditions by pharmacists or pharmacy assistants. Fifty-six samples were stored under refrigeration (3 degrees C); the remaining 56 samples were stored at room temperature (22 degrees C). Each day for 7 days, eight samples from each group were analyzed by using high-performance liquid chromatography for chemical stability and cultured for microbiological colonization. Differences in thiopental concentration between the room temperature and the refrigerated samples were measured over time by using repeated-measures analysis of variance (P < or = 0.05). Three positive culture samples (S. epidermidis and S. hemolyticus) most likely represent laboratory contamination and not col...Continue Reading

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Citations

Aug 25, 2012·International Journal of Obstetric Anesthesia·H MurdochJ Tuckey
Jul 21, 2001·Anaesthesia·A T Rayen, R Rasanayagan
Jan 5, 2002·Anaesthesia·E M Hart, W L Doherty
May 29, 2013·International Journal of Obstetric Anesthesia·Matthew Rucklidge
Jul 8, 2010·International Journal of Obstetric Anesthesia·D BoulayM Laffon
Mar 10, 2010·International Journal of Obstetric Anesthesia·A KathirgamanathanJ Douglas
May 26, 2009·International Journal of Obstetric Anesthesia·J P StoneT R Christmas
Nov 22, 2005·Veterinary Anaesthesia and Analgesia·Alexandra H A DugdaleWendy A Adams
Jan 16, 2008·The Journal of Small Animal Practice·F A StrachanR E Clutton
Nov 25, 2003·Journal of the American Veterinary Medical Association·Ann E WagnerPeter W Hellyer
Mar 2, 2013·Chemical & Pharmaceutical Bulletin·Tomoyo OhkawaYoshiyuki Kagawa

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