The chemokine receptor CXCR3 mediates rapid and shear-resistant adhesion-induction of effector T lymphocytes by the chemokines IP10 and Mig

European Journal of Immunology
L PialiB Moser

Abstract

Integrin-mediated adhesion to the vascular endothelium is an essential step in leukocyte diapedesis. We show that the chemokines 10-kDa inflammatory protein (IP10) and monokine induced by IFN (Mig) induce rapid and transient adhesion of human IL-2-stimulated T lymphocytes (IL-2 T cells) to immobilized integrin ligands through their receptor CXCR3, which is selectively expressed on activated T cells. Induction of adhesion by IP10 and Mig was already observed at subnanomolar concentrations and was maximal at 5-10 nM, resulting in three- to sixfold increase in adhesion of IL-2 T cells over background. No effect was seen with resting naive/memory T cells which lack CXCR3 and migration responses to IP10 and Mig. Both chemokines are produced in human umbilical vein endothelial cells (HUVEC) upon stimulation with IFN-gamma and TNF-alpha. These chemokines induce IL-2 T cell adhesion also when captured on the surface of endothelial cells. Under conditions of flow, IL-2 T cells roll and rapidly adhere to IP10/Mig-expressing HUVEC, and anti-CXCR3 mAb treatment reduces arrest and firm adhesion. This is the first study that shows chemokine-induced adhesion in activated memory/effector T cells which represent the fraction of T cells that are...Continue Reading

References

May 18, 1992·Journal of Immunological Methods·Y KoT Kasahara
Jul 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·J M Farber
Jan 15, 1990·Biochemical and Biophysical Research Communications·J P PaccaudM Baggiolini
Jan 24, 1986·Science·M BjerknesC A Ottaway
Mar 1, 1995·The Journal of Cell Biology·R AlonT A Springer
Oct 1, 1994·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·P LoetscherB Moser
Feb 1, 1994·Current Opinion in Immunology·C Gerard, N P Gerard
Jul 1, 1993·The Journal of Experimental Medicine·R F Bargatze, E C Butcher
Apr 15, 1993·Biochemical and Biophysical Research Communications·J M Farber
Apr 5, 1996·Science·E C Butcher, L J Picker
Jun 25, 1996·Proceedings of the National Academy of Sciences of the United States of America·S A JonesM Baggiolini
Jan 1, 1996·Annual Review of Immunology·K EbnetS Shaw
Jun 1, 1996·Cytokine & Growth Factor Reviews·P M Murphy
Nov 1, 1996·Nature Medicine·B A Premack, T J Schall
Oct 1, 1996·Current Opinion in Cell Biology·D DunonB A Imhof
Mar 4, 1997·Proceedings of the National Academy of Sciences of the United States of America·C C BleulC R Mackay
Sep 1, 1996·The Journal of Experimental Medicine·K B BaconT J Schall
Jan 1, 1997·Annual Review of Immunology·M BaggioliniB Moser
May 19, 1997·FEBS Letters·U ForssmannM Baggiolini
Mar 20, 1998·International Reviews of Immunology·B MoserP Loetscher

❮ Previous
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Citations

Jun 5, 2008·Inflammatory Bowel Diseases·Jesús Rivera-NievesKlaus Ley
Dec 25, 2004·Diabetologia·A G S van HalterenB O Roep
Jan 29, 2011·Seminars in Immunopathology·Takeshi NakajimaPatricia W Finn
Jan 13, 2005·Basic Research in Cardiology·Alma Zernecke, Christian Weber
Jan 22, 2003·Journal of Immunological Methods·Carlo Laudanna, Gabriela Constantin
Oct 11, 2003·Experimental Hematology·Ulrich DuffnerJames L M Ferrara
Oct 31, 1998·Current Opinion in Immunology·D M BriscoeA H Lichtman
Sep 7, 2001·Current Opinion in Cell Biology·R A Worthylake, K Burridge
Mar 20, 2002·Cytokine & Growth Factor Reviews·Mario P Colombo, Giorgio Trinchieri
Mar 29, 2002·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Kouetsu OgasawaraTadatsugu Taniguchi
Jul 5, 2001·Neuropathology and Applied Neurobiology·S H GoldbergE Lavi
Sep 13, 2002·Immunology and Cell Biology·Lois L Cavanagh, Ulrich H Von Andrian
Jun 8, 1999·The Journal of Experimental Medicine·H XieA H Lichtman
Nov 13, 1998·Current Opinion in Lipidology·R TerkeltaubL K Curtiss
Jan 10, 2001·Inflammatory Bowel Diseases·K A Papadakis, S R Targan
Nov 27, 2001·Inflammatory Bowel Diseases·Y H YuanA A te Velde
Feb 28, 2003·Transplantation·Hirohito KobayashiRobert L Fairchild
Oct 27, 2009·Transplantation·Jean Kwun, Stuart J Knechtle
Mar 29, 2011·Transplantation·Denise J LoAllan D Kirk
Sep 3, 2008·Journal of Gastroenterology and Hepatology·Pinelopi ManousouElias Kouroumalis
Apr 15, 2004·Annals of the Rheumatic Diseases·J J HaringmanP P Tak
Dec 14, 2011·Clinical & Developmental Immunology·Carola T MurphySilvia Melgar
May 2, 2003·American Journal of Respiratory and Critical Care Medicine·Stephanie SénéchalBenoît Wallaert
Jul 7, 1999·The Journal of Clinical Investigation·L TrentinG Semenzato
Mar 4, 2005·Arthritis Research & Therapy·Georgia MartiniCarlo Agostini
Dec 8, 2014·Best Practice & Research. Clinical Rheumatology·Rikesh PatelChristopher D Buckley
Jun 18, 2009·Seminars in Immunopathology·Andrea T BorchersM Eric Gershwin

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