The chemopreventive efficacy of inhaled oltipraz particulates in the B[a]P-induced A/J mouse lung adenoma model

Carcinogenesis
Sheela SharmaVernon E Steele

Abstract

This study explored the efficacy of oltipraz, a dithiolthione to prevent lung cancer by delivering it directly to the lung as inhaled particulates to obtain maximum efficacy with no toxicity. Two exposure regimens were used to compare the efficacies of early (Regimen-A) versus late (Regimen-B) intervention in prevention of lung tumorigenesis in A/J mice. Female A/J mice were exposed to 10, 30 and 100 mg/m(3) exposure concentrations of oltipraz for 1.0 h a day for 5 days per week for 4 weeks in Regimen A. During the second and third week, mice received totally 6 mg of B[a]P via gavage and after 16 weeks, they were killed for tumor counting and pathology. In Regimen B, mice were treated first with B[a]P and, after a gap of 4 weeks, exposed to oltipraz at 100 mg/m(3) for 16 additional weeks. At 22 weeks, animals were killed and necropsied for tumor scoring. The spontaneous tumors were few in untreated A/J mice (0.7 tumors/lung), whereas there was an average of 16.5 tumors per lung in the B[a]P group (20-fold induction). Evaluation of lung tumor multiplicity following exposure to oltipraz showed that oltipraz inhibited the tumor development in a dose-dependent manner (10-100 mg/m(3)) with inhibition ranging from 37 to 53% in Regime...Continue Reading

Citations

Nov 13, 2008·Molecular Cancer Therapeutics·Yuesheng Zhang, Rex Munday
May 13, 2011·Cancer Prevention Research·Sheela SharmaVernon E Steele
Oct 22, 2013·Genes & Development·Melba C Jaramillo, Donna D Zhang
Jun 3, 2011·International Journal of Toxicology·Sheela SharmaVernon E Steele
Jan 16, 2010·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Dandan Yi, Timothy Scott Wiedmann
Feb 29, 2016·Journal of Hematology & Oncology·Yijun TianKongming Wu
Feb 8, 2019·Oxidative Medicine and Cellular Longevity·Qinmei LiuXinxin Ci
Nov 17, 2016·Oxidative Medicine and Cellular Longevity·Angelo SparaneoLucia Anna Muscarella
Aug 23, 2019·International Journal of Molecular Sciences·Simona PompiliGiovanni Latella
Feb 15, 2019·Cancer Research·Erica W CloerMichael B Major
Aug 28, 2021·Cells·Miriam Sánchez-OrtegaAntonio Garrido
Feb 3, 2009·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Xiang-Lin Tan, Simon D Spivack
Sep 8, 2009·Toxicology and Applied Pharmacology·Mi-Kyoung Kwak, Thomas W Kensler

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