PMID: 339856Dec 1, 1977Paper

The chemotherapy of rodent malaria, XXVII. Studies on mefloquine (WR 142,490)

Annals of Tropical Medicine and Parasitology
W PetersD C Warhurst

Abstract

Mefloquine (WR 142,490) is a potent blood schizontocide active against drug-sensitive and drug-resistant lines of Plasmodium berghei. The ED50 and ED90 against the P. berghei N strain in albino mice are 1.5 and 3.8 mg/kg respectively. The highly chloroquine-resistant RC line is less sensitive and mefloquine is not fully effective at the maximum tolerated dose in the '4-day test'. Mefloquine has a similar mode of action to quinine both in vitro and (as demonstrated by the morphological changes it induces in P. berghei) in vivo, but is some 100 times more potent. Unlike quinine and WR 122,455 it appears not to interact with DNA. It has no causal prophylactic effect. Mixtures of mefloquine with pyrimethamine, sulphaphenazole or primaquine have an additive effect.

References

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Citations

May 30, 2014·Parasitology·Abebe Genetu Bayih, Dylan R Pillai
Jun 26, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sara E McCartyAngela I Calderón
Jan 1, 1985·Transactions of the Royal Society of Tropical Medicine and Hygiene·L L SmrkovskiC V Uylangco
Oct 1, 1987·Annals of Tropical Medicine and Parasitology·W PetersD S Ellis
Jun 3, 2004·Nature Reviews. Drug Discovery·David A FidockSolomon Nwaka
Jul 1, 1989·Transactions of the Royal Society of Tropical Medicine and Hygiene·E C ReisingerM Dietrich
Jan 1, 1986·Transactions of the Royal Society of Tropical Medicine and Hygiene·A A CrouchY H Thong
Feb 1, 1980·Annals of Tropical Medicine and Parasitology·B MerkliW Peters
Jan 1, 1981·Medicinal Research Reviews·T R Sweeney
Nov 17, 2012·BMC Infectious Diseases·Rafika ZatraFousseyni S Toure Ndouo
Oct 1, 1988·Revista Da Sociedade Brasileira De Medicina Tropical·J B Santos, A Prata
Dec 1, 1977·Annals of Tropical Medicine and Parasitology·W PetersB L Robinson
Dec 15, 1981·Biochemical Pharmacology·D C Warhurst
Nov 19, 1979·Life Sciences·R E BrownA D Wolfe
Feb 1, 1993·Pharmacology & Therapeutics·A F Slater
Mar 23, 1984·Biochimica Et Biophysica Acta·R C San GeorgeM E Fabry
Feb 1, 1979·Antimicrobial Agents and Chemotherapy·C D FitchR Chevli
Mar 1, 1990·Parasitology Today·S R Meshnick

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