The ChemTrak Hp Chek fingerstick whole blood serology test for the detection of Helicobacter pylori infection

The American Journal of Gastroenterology
W D CheyH M El-Zimaity

Abstract

To evaluate a new whole blood serology test (Hp Chek; ChemTrak) that detects IgG antibodies to Helicobacter pylori. The study was conducted at 10 sites within the United States. Patients undergoing upper endoscopy for dyspepsia were recruited for enrollment. Those treated for H. pylori infection within a year of endoscopy and those who had regularly used proton pump inhibitors, bismuth compounds, or antibiotics within a month of endoscopy were not eligible. During endoscopy, specimens were obtained from the corpus and antrum for histological examination, which was performed by a single experienced pathologist. The Hp Chek was tested using whole blood and serum. Serum was also tested with a reference enzyme-linked immunosorbent assay (ELISA) at a centralized location. Test characteristics for the Hp Chek and ELISA were calculated using histology as the "gold standard." Two hundred eighty-seven patients (140 women and 147 men; mean age 53 +/- 6 yr) were enrolled. The Hp Chek was easy to perform and yielded results 9 min after inoculation of the test cassette with whole blood or serum. When the Hp Chek used with whole blood was compared with histology as the gold standard, the sensitivity was 88%, specificity 85%, positive predict...Continue Reading

Citations

Mar 16, 2018·The Cochrane Database of Systematic Reviews·Lawrence Mj BestKurinchi Selvan Gurusamy
Sep 7, 2001·International Journal of Cognitive Ergonomics·A D PartonB De Bruyn
Nov 26, 1999·Alimentary Pharmacology & Therapeutics·D J KearneyJ S Peacock
Oct 26, 2000·Alimentary Pharmacology & Therapeutics·D VairaM Miglioli

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