PMID: 11312111Apr 20, 2001Paper

The chicken Chemotactic and Angiogenic Factor (cCAF), a CXC chemokine

The International Journal of Biochemistry & Cell Biology
Manuela Martins-Green

Abstract

The chemokine cCAF (&cmacr;hicken &Cmacr;hemotactic and Angiogenic &Fmacr;actor), is the product of the 9E3/CEF4 gene. Its name reflects the biological properties of the protein: chemotactic and angiogenic. This CXC chemokine is highly homologous to human IL-8, both at the protein and gene level. Molecular modeling based on the known structure of IL-8 shows that the structure of cCAF is very similar to that of other CXC chemokines. Regulation of expression occurs both at the transcriptional and post-transcriptional levels. The cCAF protein is secreted very rapidly as a 9kDa molecule and can be cleaved in the N-terminus after secretion to produce a smaller form ( approximately 7kDa) that binds to ECM molecules. Plasmin, an enzyme present in the early stages of wound healing and in tumor stroma, cleaves the 9kDa to the 7kDa form. The biological properties of this chemokine and its patterns of expression in vivo strongly suggest that cCAF plays important roles in traumatic and pathological conditions.

References

Dec 1, 1988·The Journal of Cell Biology·E J MackieD Liverani
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Feb 21, 1998·Nucleic Acids Research·T HeinemeyerN A Kolchanov

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Citations

Apr 6, 2004·Developmental and Comparative Immunology·Kerry J Laing, Christopher J Secombes
Jan 19, 2002·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·P StaeheliB Kaspers
Apr 4, 2008·Journal of Virology·Gerlinde R Van de WalleNikolaus Osterrieder
Dec 23, 2006·Expert Review of Vaccines·Keith W JarosinskiNikolaus Osterrieder
May 1, 2006·Environmental Toxicology and Pharmacology·Sohail Ejaz, Chae Woong Lim
May 1, 2006·Environmental Toxicology and Pharmacology·Sohail Ejaz, Chae Woong Lim
Oct 15, 2011·Critical Reviews in Microbiology·David HermansFreddy Haesebrouck
Jun 23, 2009·Drug and Chemical Toxicology·Sohail EjazChae Woong Lim
Jan 25, 2006·Developmental and Comparative Immunology·Enav Bar-Shira, Aharon Friedman
Feb 10, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Qi-Jing LiManuela Martins-Green

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