The chicken or the egg? Does glycaemic control predict cognitive function or the other way around?

Diabetologia
Ithamar Ganmore, Michal Schnaider Beeri

Abstract

The association between type 2 diabetes and cognitive dysfunction is well established. Prevention of the development of type 2 diabetes and its complications, as well as cognitive dysfunction and dementia, are leading goals in these fields. Deciphering the causality direction of the interplay between type 2 diabetes and cognitive dysfunction, and understanding the timeline of disease progression, are crucial for developing efficient prevention strategies. The prevailing perception is that type 2 diabetes leads to cognitive dysfunction and dementia. There is substantial evidence showing that accelerated cognitive decline in type 2 diabetes starts in midlife (mean age 40-60 years) and that it may even begin at the prediabetes stage. However, in this issue of Diabetologia, Altschul et al (doi: https://doi.org/10.1007/s00125-018-4645-8 ) show evidence for the reverse causality hypothesis, i.e. that lower cognitive function precedes poor glycaemic control. They found that cognitive function at early adolescence (age 11 years) predicts both HbA1c levels and cognitive function at age 70 years. Moreover, they found that lower cognitive function at age 70 is associated with an increase in HbA1c from age 70 to 79 years. Based on these fi...Continue Reading

References

May 19, 2004·Archives of Neurology·Zoe ArvanitakisDavid A Bennett
Nov 24, 2004·Neurology·M Schnaider BeeriM Davidson
Dec 18, 2008·Dementia and Geriatric Cognitive Disorders·S MaggiUNKNOWN ILSA Study Group
Nov 13, 2009·Diabetes Care·Vivian A Fonseca
Apr 29, 2011·Journal of Human Genetics·Sandra J HasstedtSteven C Elbein
Jul 22, 2011·Lancet Neurology·Deborah E Barnes, Kristine Yaffe
Mar 20, 2012·Journal of Alzheimer's Disease : JAD·Ramit Ravona-SpringerMichal Schnaider Beeri
Jun 20, 2012·Archives of Neurology·Kristine YaffeTamara B Harris
Aug 9, 2013·The New England Journal of Medicine·Paul K CraneEric B Larson
Aug 14, 2013·Diabetes Care·Chris MoranVelandai Srikanth
Aug 27, 2013·Journal of Psychosomatic Research·René MõttusIan J Deary
Nov 29, 2013·The New England Journal of Medicine·Eric B LarsonKenneth M Langa
Mar 14, 2014·The Lancet. Diabetes & Endocrinology·Geert Jan BiesselsRachel A Whitmer
Aug 6, 2014·Diabetes Care·Gilad TwigTali Cukierman-Yaffe
Dec 2, 2014·Annals of Internal Medicine·Andreea M RawlingsElizabeth Selvin
Jan 21, 2015·Health Psychology : Official Journal of the Division of Health Psychology, American Psychological Association·René MõttusIan J Deary
Feb 5, 2015·Alzheimer Disease and Associated Disorders·Elizabeth R MayedaJohn Neuhaus
Feb 17, 2015·World Journal of Diabetes·Klaus-Dieter KohnertEckhard Salzsieder
Jun 23, 2015·Journal of the American Geriatrics Society·Katherine J BangenJosé A Luchsinger
Oct 3, 2015·The Journal of Clinical Endocrinology and Metabolism·Tali Cukierman-YaffeGilad Twig
Mar 2, 2016·Current Pharmaceutical Biotechnology·Antonio Gonzalez-BulnesMarta Vazquez-Gomez
May 14, 2017·Diabetes Care·Andreea M RawlingsElizabeth Selvin
Jul 14, 2017·Clinical Diabetes and Endocrinology·Paul Z Zimmet
Oct 28, 2017·Diabetes Care·Aaron LeongJames B Meigs
Dec 10, 2017·Diabetes Care·UNKNOWN American Diabetes Association
Dec 10, 2017·Diabetes Care·UNKNOWN American Diabetes Association

❮ Previous
Next ❯

Citations

Sep 16, 2019·Hormones : International Journal of Endocrinology and Metabolism·Marianna KarvaniD Kapoukranidou
Feb 8, 2020·International Journal of Nursing Practice·Heather E CuevasSharon A Brown
Dec 31, 2020·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Naoya EmotoHitoshi Sugihara

❮ Previous
Next ❯

Related Concepts

Related Feeds

Biomarkers for Type 2 Diabetes

Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.

Related Papers

Annals of Internal Medicine
Andreea M RawlingsElizabeth Selvin
Diabetic Medicine : a Journal of the British Diabetic Association
R Singh, M Press
Nursing Times
Jill Rodgers, Rosemary Walker
The New Zealand Medical Journal
Helen LuntBrian A Darlow
© 2022 Meta ULC. All rights reserved