The chicken or the egg: PHEX, FGF23 and SIBLINGs unscrambled.

Cell Biochemistry and Function
Peter S N Rowe

Abstract

The eggshell is an ancient innovation that helped the vertebrates' transition from the oceans and gain dominion over the land. Coincident with this conquest, several new eggshell and noncollagenous bone-matrix proteins (NCPs) emerged. The protein ovocleidin-116 is one of these proteins with an ancestry stretching back to the Triassic. Ovocleidin-116 is an avian homolog of Matrix Extracellular Phosphoglycoprotein (MEPE) and belongs to a group of proteins called Small Integrin-Binding Ligand Interacting Glycoproteins (SIBLINGs). The genes for these NCPs are all clustered on chromosome 5q in mice and chromosome 4q in humans. A unifying feature of the SIBLING proteins is an Acidic Serine Aspartate-Rich MEPE (ASARM)-associated motif. The ASARM motif and the released ASARM peptide play roles in mineralization, bone turnover, mechanotransduction, phosphate regulation and energy metabolism. ASARM peptides and motifs are physiological substrates for phosphate-regulating gene with homologies to endopeptidases on the X chromosome (PHEX), a Zn metalloendopeptidase. Defects in PHEX are responsible for X-linked hypophosphatemic rickets. PHEX interacts with another ASARM motif containing SIBLING protein, Dentin Matrix Protein-1 (DMP1). DMP1 m...Continue Reading

References

Jul 1, 1975·Clinical Science and Molecular Medicine·R J WaltonR Smith
Aug 1, 1975·The American Journal of Physiology·J P BonjourL A Baxter
Jul 1, 1992·Human Genetics·P S RoweJ L O'Riordan
Nov 1, 1992·Matrix : Collagen and Related Research·W T ButlerR A Foster
Apr 1, 1992·Computer Applications in the Biosciences : CABIOS·X HuangR C Hardison
Jan 1, 1991·Kidney International·X J ZhouS G Massry
Oct 1, 1990·Computer Applications in the Biosciences : CABIOS·X Q HuangW Miller
Jan 1, 1988·Clinical Science·P J Lawson-MatthewJ A Kanis
Jul 29, 1988·Biochemical and Biophysical Research Communications·B LenarcicV Turk
Jun 1, 1988·Clinical Science·E V McCloskeyJ A Kanis
Jul 14, 1987·Biochemistry·R C Bateman, L B Hersh
Jun 20, 1973·Biochimica Et Biophysica Acta·K Kurokawa, H Rasmussen
Nov 27, 1980·The New England Journal of Medicine·R A DeFronzo, R Lang
Sep 1, 1995·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·T NesbittM K Drezner
Apr 21, 1995·Annals of the New York Academy of Sciences·A L Boskey
Nov 25, 1994·Nucleic Acids Research·P S RoweJ Goulding
Apr 1, 1994·Human Molecular Genetics·M J EconsP A Becker
Jul 1, 1993·Human Genetics·P S RoweK E Davies
Sep 6, 1996·The Journal of Biological Chemistry·H H Ritchie, L H Wang
Dec 1, 1996·Computer Applications in the Biosciences : CABIOS·L DuretG Perrière
Sep 1, 1997·Calcified Tissue International·L RifasL V Avioli
Jun 6, 1998·Proceedings of the National Academy of Sciences of the United States of America·L BeckH S Tenenhouse
Jul 11, 1998·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·F J PaulaM C Foss
Aug 5, 1998·Current Opinion in Nephrology and Hypertension·P S Rowe
Dec 10, 1998·Nucleic Acids Research·N D Rawlings, A J Barrett
Oct 8, 1999·The Biochemical Journal·W XieG Van De Werve

❮ Previous
Next ❯

Citations

Jan 28, 2014·BoneKEy Reports·Roger Bouillon, Tatsuo Suda
Oct 14, 2014·Current Otorhinolaryngology Reports·Cameron C WickCliff A Megerian
Dec 3, 2014·Molecular and Cellular Endocrinology·Nobuaki ItoGerald J Atkins
Sep 24, 2015·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Sandro Mazzaferro, Marzia Pasquali
Jan 15, 2016·Matrix Biology : Journal of the International Society for Matrix Biology·Wafa BouleftourLuc Malaval
Dec 22, 2015·Matrix Biology : Journal of the International Society for Matrix Biology·Priyam H JaniChunlin Qin
Sep 17, 2013·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Quan YuanBeate Lanske
Sep 10, 2014·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Iris LindbergKevin Z Li
Sep 13, 2015·Journal of Translational Medicine·Sandra R Boiça SilvaDanuza Esquenazi
Apr 17, 2015·Current Opinion in Pharmacology·Peter S Rowe
Jun 25, 2013·Molecular and Cellular Endocrinology·Katie J WelldonGerald J Atkins
Jan 15, 2014·Lancet·Charlotte Jane Elder, Nicholas J Bishop
Nov 5, 2014·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Y AsamiyaK Nitta
Dec 17, 2014·Seminars in Nephrology·Sandro MazzaferroMarzia Pasquali
Jan 23, 2016·Rheumatology·Roland D Chapurlat, Cyrille B Confavreux
Oct 14, 2016·American Journal of Otolaryngology·Cameron C WickQing Yin Zheng
May 29, 2015·Veterinary Pathology·M R Hardcastle, K E Dittmer
Mar 22, 2013·Proceedings. Biological Sciences·Erik P WillemsCarel P van Schaik
Jul 9, 2016·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Chang-Yun YoonTae-Hyun Yoo
May 28, 2016·Nature Reviews. Endocrinology·Lilian I Plotkin, Teresita Bellido
Aug 18, 2020·JBMR Plus·Brian ChristensenEsben S Sørensen
Feb 14, 2021·BMC Molecular and Cell Biology·J GautronM T Hincke
Jul 28, 2020·Molecular and Cellular Endocrinology·Tomoko MinamizakiYuji Yoshiko
May 29, 2021·Frontiers in Genetics·Nathalie Le RoyMaxwell T Hincke

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