The chitin synthase involved in marine bivalve mollusk shell formation contains a myosin domain

FEBS Letters
Ingrid M WeissManfred Sumper

Abstract

Chitin is a key component in mollusk nacre formation. However, the enzyme complex responsible for chitin deposition in the mollusk shell remained unknown. We cloned and characterized the chitin synthase of the marine bivalve mollusk Atrina rigida. We present here the first chitin synthase sequence from invertebrates containing an unconventional myosin motor head domain. We further show that a homologous gene for chitin synthase is expressed in the shell forming tissue of larval Mytilus galloprovincialis even in early embryonic stages. The new data presented here are the first clear-cut indication for a functional role of cytoskeletal forces in the precisely controlled mineral deposition process of mollusk shell biogenesis.

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Citations

Nov 17, 2009·Molecular Biology and Evolution·Daniel J JacksonBernard M Degnan
Sep 16, 2008·BMC Developmental Biology·Gustavo Lazzaro RezendeDenise Valle
Nov 8, 2007·BMC Structural Biology·Veronika Schönitzer, Ingrid M Weiss
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Nov 15, 2011·Biochemical and Biophysical Research Communications·Veronika SchönitzerIngrid M Weiss
Apr 18, 2016·Journal of Structural Biology·Frédéric MarinDavorin Medakovic
May 7, 2013·Journal of Structural Biology·Ingrid M WeissHauke Clausen-Schaumann
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Sep 22, 2019·International Journal of Molecular Sciences·Tomohisa OgawaHiroaki Tateno

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