PMID: 7543751Aug 1, 1995Paper

The chloride effect in the human embryonic haemoglobins

The Biochemical Journal
O HofmannT Brittain

Abstract

The interactions of the three human embryonic haemoglobins with chloride ions have been investigated. Each of the three embryonic haemoglobins exhibits a unique pattern of oxygen-affinity-dependence on chloride ion concentration. Human embryonic haemoglobin Portland (zeta 2 gamma 2) is found to be completely insensitive to chloride ion concentration. Haemoglobin Gower I (zeta 2 gamma 2) shows a small concentration dependence, whilst haemoglobin Gower II (alpha 2 epsilon 2) exhibits a dependence approaching that of the adult protein. The degree of co-operativity for each protein is essentially chloride concentration independent. The chloride-dependent and -independent components of the alkaline Bohr effects have been measured for each of the embryonic haemoglobins and compared with that of the adult protein. Both the chloride-binding data and the Bohr effect have been analysed in terms of the recently developed allosteric model proposed by Perutz [Perutz, Fermi, Poyart, Pagnier and Kister (1993) J. Mol. Biol. 233, 536-545].

Citations

May 31, 2013·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Roy E WeberThomas A Gorr
Apr 7, 2012·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Kevin L CampbellRoy E Weber
Sep 17, 2020·The Biochemical Journal·Chandrasekhar NatarajanJay F Storz
Jul 20, 2010·The Journal of Experimental Biology·Jay F StorzAngela Fago
Nov 15, 1996·Journal of Inorganic Biochemistry·N Robson, T Brittain
Jul 4, 2002·Molecular Aspects of Medicine·Thomas Brittain
Apr 19, 2008·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Kristen HentyThomas Brittain
Oct 28, 2021·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Naim M BautistaAngela Fago

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