PMID: 7334456Sep 1, 1981Paper

The choleretic mechanism of coumarin compounds and phenolic compounds

Journal of Pharmacobio-dynamics
S Takeda, M Aburada

Abstract

In this work, the choleretic properties and mechanism of coumarin compounds and phenolic compounds were studied by examining their effects on parameters such as bile flow, bile acids, electrolytes, and biliary metabolites. Choleretic intensity and property of each sample was far different. The choleretic efficacy of 6, 7-dimethylesculetin (6,7-DME) was far weaker than that of 4 methylumbelliferone (4-MU). 4-hydroxybenzyl alcohol (4-HBA), isoeugenol, vanillin, paeonol, and phenolphthalein accelerated bile secretion, but 4 (B-D-glucopyranosyloxy)-benzyl alcohol, safrol, and arbutin did not. 4-MU and 4-HBA underwent conjugation in the liver to give mainly a glucuronide and their metabolites were rapidly excreted into bile, but 6, 7-DME was converted into some metabolites which were excreted little by little over a long period of time. The biliary gap between cations (NA+, K+) and anions (CL-, HCO3-, bile acids) produced after intravenous administration of 4-MU, 6, 7-DME, and 4-HBA was substantially offset by biliary concentrations of their metabolites. It was suggested that a hydroxyl group which can be mainly converted into a glucuronide is necessary in exerting a strong choleretic action. The choleretic mechanism of coumarin co...Continue Reading

Citations

Jun 25, 2015·Molecular Therapy : the Journal of the American Society of Gene Therapy·Mariana MalviciniGuillermo Mazzolini
May 25, 2016·Clinical and Experimental Immunology·H F KuipersP L Bollyky
Apr 5, 2005·European Journal of Medicinal Chemistry·Yogesh K TyagiRajinder K Gupta
Nov 2, 2017·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Shunsuke HamadaNaoki Ishiguro
Jun 11, 2004·The Journal of Biological Chemistry·Ikuko KakizakiNaoki Itano
Nov 16, 2007·The Journal of Obstetrics and Gynaecology Research·Kanji TanakaKeiichi Takagaki
Jan 1, 1992·Drug Metabolism and Drug Interactions·G Feuer, C J Di Fonzo
Mar 28, 2019·The Journal of Biological Chemistry·Nadine NagyPaul L Bollyky
Jul 9, 2017·British Journal of Pharmacology·Scott D CollumHarry Karmouty-Quintana

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.