The cholinergic anti-inflammatory pathway revisited

Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society
K Murray, C Reardon

Abstract

Inflammatory bowel disease negatively affects the quality of life of millions of patients around the world. Although the precise etiology of the disease remains elusive, aberrant immune system activation is an underlying cause. As such, therapies that selectively inhibit immune cell activation without broad immunosuppression are desired. Inhibition of immune cell activation preventing pro-inflammatory cytokine production through neural stimulation has emerged as one such treatment. These therapeutics are based on the discovery of the cholinergic anti-inflammatory pathway, a reflex arc that induces efferent vagal nerve signaling to reduce immune cell activation and consequently mortality during septic shock. Despite the success of preclinical and clinical trials, the neural circuitry and mechanisms of action of these immune-regulatory circuits are controversial. At the heart of this controversy is the protective effect of vagal nerve stimulation despite an apparent lack of neuroanatomical connections between the vagus and target organs. Additional studies have further emphasized the importance of sympathetic innervation of these organs, and that alternative neural circuits could be involved in neural regulation of the immune sys...Continue Reading

References

Jan 1, 1991·Journal of Neuroimmunology·X X HuC F Brosnan
Dec 1, 1989·Brain, Behavior, and Immunity·D L BellingerD L Felten
Dec 1, 1988·Brain, Behavior, and Immunity·D L Felten, S Y Felten
Feb 1, 1993·Journal of the Autonomic Nervous System·H R Berthoud, T L Powley
May 5, 1999·Journal of Anatomy·A L PanuncioN Reissenweber
Feb 28, 2002·Annual Review of Immunology·Warren StroberRichard S Blumberg
Dec 20, 2002·Nature·Kevin J Tracey
Mar 15, 2005·The Journal of Clinical Investigation·Kyoko KatakuraEyal Raz
Aug 30, 2005·Annals of the New York Academy of Sciences·Helena Tlaskalová-HogenováPaul Bland
May 1, 2007·Brain, Behavior, and Immunity·Dwight M Nance, Virginia M Sanders
Jun 23, 2007·American Journal of Physiology. Gastrointestinal and Liver Physiology·Jean-Eric GhiaStephen M Collins
Aug 4, 2007·American Journal of Physiology. Gastrointestinal and Liver Physiology·Jean-Eric GhiaStephen M Collins
Oct 20, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Bradford E BerndtJohn Y Kao
May 22, 2008·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·V VasinaF de Ponti
Mar 7, 2009·American Journal of Physiology. Gastrointestinal and Liver Physiology·Mohamed A MotagallyAlan E Lomax
Nov 20, 2009·The New England Journal of Medicine·Clara Abraham, Judy H Cho
Nov 13, 2010·Autonomic Neuroscience : Basic & Clinical·J MeregnaniBruno Bonaz
Mar 26, 2013·Journal of Crohn's & Colitis·Vincent BillioudLaurent Peyrin-Biroulet
Apr 13, 2013·Nature·Kristoffer FammMoncef Slaoui
Aug 24, 2013·The New England Journal of Medicine·Ole Haagen Nielsen, Mark Andrew Ainsworth
Aug 24, 2013·Nature·Isaac M ChiuClifford J Woolf
Nov 12, 2013·Expert Opinion on Biological Therapy·Thomas BillietSéverine Vermeire
Jan 15, 2014·The Journal of Physiology·D MartelliR M McAllen
Sep 2, 2015·Nature Reviews. Gastroenterology & Hepatology·Gilaad G Kaplan
Feb 28, 2016·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·B BonazS Pellissier
Mar 19, 2016·Neuromodulation : Journal of the International Neuromodulation Society·Imanuel LermanDewleen G Baker
Apr 19, 2016·The Journal of Clinical Investigation·Tsuyoshi InoueMark D Okusa
Jul 7, 2016·Proceedings of the National Academy of Sciences of the United States of America·Frieda A KoopmanPaul P Tak
Nov 4, 2016·American Journal of Physiology. Gastrointestinal and Liver Physiology·Shobhit DhawanWouter J de Jonge
Oct 30, 2016·Trends in Immunology·Felipe A Pinho-RibeiroIsaac M Chiu
Jan 14, 2017·American Journal of Physiology. Gastrointestinal and Liver Physiology·Alan E LomaxPaul P Bertrand
Mar 14, 2017·Nature Neuroscience·Chikara AbePatrice G Guyenet

❮ Previous
Next ❯

Citations

Dec 24, 2018·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Davide MartelliRobin M McAllen
Oct 24, 2018·Journal of Neurogastroenterology and Motility·Meng-Juan Lin, Bao-Ping Yu
Feb 12, 2019·Bioelectronics in Medicine·Alexandre KanashiroLuis Ulloa
Aug 8, 2020·Nature Reviews. Gastroenterology & Hepatology·Alan de Araujo, Guillaume de Lartigue
Oct 22, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Dong-Ping XieYun Han
Mar 7, 2020·International Immunopharmacology·Donald B HooverTammy R Ozment
Jan 8, 2019·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Elinor C MannonPaul M O'Connor
Jul 1, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Kai KangKai-Jiang Yu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here