Abstract
Inter-alpha-inhibitor (IalphaI) and pre-alpha-inhibitor (PalphaI) are the main members of a set of multichain serine proteinase inhibitors. Present in human plasma, they may be involved in control of the inflammatory process. They are composed of homologous heavy chains (H1 and H2 for IalphaI; H3 for PalphaI) covalently linked by a protein-glycosaminoglycan-protein cross-link to bikunin, which is a chondroitin 4-sulfate proteoglycan. During the acute-phase response, biosynthesis of IalphaI and PalphaI is downregulated and upregulated, respectively. In this work, we provide evidence that, in inflammatory diseases, the chondroitin sulfate chain of bikunin increases in size proportionally to the severity of the inflammatory response. As a consequence, all IalphaI-related components that contain bikunin are structurally modified. Therefore, the changes in glycosylation of the acute-phase proteins are not restricted to N-linked glycans but also affect glycosaminoglycans. The implications of these findings are discussed with regard to biosynthesis and biological role, especially the anti-inflammatory effects of IalphaI-related proteinase inhibitors.
References
Oct 1, 1992·Chemical & Pharmaceutical Bulletin·H ToyodaT Imanari
May 1, 1992·Journal of Pharmacobio-dynamics·T ImanariH Toyoda
Sep 1, 1990·Biological Chemistry Hoppe-Seyler·B GressierJ Mizon
Jun 1, 1986·Analytical Biochemistry·H Min, M K Cowman
Jan 1, 1987·Biological Chemistry Hoppe-Seyler·L SelloumJ Mizon
Aug 15, 1970·Nature·U K Laemmli
May 11, 1968·Nature·J Uriel, J Berges
Jan 1, 1994·Vox Sanguinis·C MichalskiJ Mizon
Oct 15, 1995·European Journal of Biochemistry·S YamadaK Sugahara
Oct 30, 1995·FEBS Letters·A HéronR Sesboüé
Jun 1, 1993·The Biochemical Journal·M DaveauJ P Salier
Jan 26, 1995·Biochemical and Biophysical Research Communications·K MaeharaT Terao
Mar 28, 1996·Journal of Immunological Methods·C MizonJ Mizon
Apr 1, 1996·The Biochemical Journal·J P SalierM Daveau
Aug 1, 1996·Journal of Biochemistry·H ItohY Nawa
Mar 7, 1997·Biochimica Et Biophysica Acta·O CarretteJ Mizon
May 9, 1997·Journal of Chromatography. B, Biomedical Sciences and Applications·C MizonJ Mizon
Jun 30, 1997·FEBS Letters·A A Parkar, A J Day
Sep 23, 1997·Biochemical and Biophysical Research Communications·N KanayamaT Terao
Dec 31, 1997·American Journal of Respiratory and Critical Care Medicine·M JourdainC Chopin
Mar 3, 1998·Biochemical and Biophysical Research Communications·Y KatoK Hoshida
Sep 10, 1999·The Journal of Biological Chemistry·E WilharmD E Jenne
Oct 8, 1999·Biochemistry·J J EnghildH Rahbek-Nielsen
Jan 5, 2000·European Journal of Clinical Investigation·C MizonJ Mizon
Mar 1, 2000·The Journal of Laboratory and Clinical Medicine·M BalduyckJ Mizon
Mar 21, 2000·Journal of Cellular Biochemistry·E Tufvesson, G Westergren-Thorsson
May 10, 2000·The Journal of Biological Chemistry·H KobayashiT Terao
Citations
Nov 23, 2006·Glycoconjugate Journal·Michael J PugiaSubhash C Basu
May 27, 2003·Biochimie·Calliope CaponJacques Mizon
Jan 18, 2005·Clinical Chemistry and Laboratory Medicine : CCLM·Michael J Pugia, John A Lott
Jun 24, 2003·The American Journal of Pathology·Carol A de la MotteScott A Strong
Aug 18, 2005·BJU International·Lizhu YangSusan Ruth Marengo
Jan 5, 2012·Biochemistry Research International·Elisabetta ZinelluMarilena Formato
Nov 20, 2012·Biochimie·Lise BervenAnne Berit C Samuelsen
Dec 19, 2006·Biochimica Et Biophysica Acta·Ikuko KakizakiKeiichi Takagaki
Sep 27, 2015·Molecular & Cellular Proteomics : MCP·Alejandro Gomez ToledoGöran Larson
Feb 4, 2010·Proteomics·Alan D PembertonNeil F Inglis
Nov 11, 2014·Expert Review of Molecular Diagnostics·Megan S LordJohn M Whitelock
Dec 5, 2019·Journal of Neuroscience Research·Boram KimBarbara S Stonestreet
Mar 16, 2018·Journal of Diabetes Research·Antonio Junior LepeddaMarilena Formato
Jul 9, 2020·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Megan S LordJohn M Whitelock
Jun 14, 2002·FEBS Letters·Tomoyasu SugiyamaTakao Isogai
Jun 27, 2013·The Journal of Biological Chemistry·Megan S LordJohn M Whitelock
Feb 6, 2008·Journal of the American Chemical Society·Lianli ChiRobert J Linhardt
Aug 24, 2011·International Journal of Mass Spectrometry·Tatiana N LaremoreRobert J Linhardt