The chromatin basis of neurodevelopmental disorders: Rethinking dysfunction along the molecular and temporal axes.

Progress in Neuro-psychopharmacology & Biological Psychiatry
Michele GabrieleGiuseppe Testa

Abstract

The complexity of the human brain emerges from a long and finely tuned developmental process orchestrated by the crosstalk between genome and environment. Vis à vis other species, the human brain displays unique functional and morphological features that result from this extensive developmental process that is, unsurprisingly, highly vulnerable to both genetically and environmentally induced alterations. One of the most striking outcomes of the recent surge of sequencing-based studies on neurodevelopmental disorders (NDDs) is the emergence of chromatin regulation as one of the two domains most affected by causative mutations or Copy Number Variations besides synaptic function, whose involvement had been largely predicted for obvious reasons. These observations place chromatin dysfunction at the top of the molecular pathways hierarchy that ushers in a sizeable proportion of NDDs and that manifest themselves through synaptic dysfunction and recurrent systemic clinical manifestation. Here we undertake a conceptual investigation of chromatin dysfunction in NDDs with the aim of systematizing the available evidence in a new framework: first, we tease out the developmental vulnerabilities in human corticogenesis as a structuring entry...Continue Reading

Citations

Nov 22, 2019·Developmental Medicine and Child Neurology·Deniz Aygun, Hans T Bjornsson
Aug 15, 2019·Human Molecular Genetics·Alessandro VitrioloGiuseppe Testa
Jul 15, 2020·International Journal of Molecular Sciences·Maria Victoria Niklison-ChirouGerry Melino
Aug 1, 2019·International Journal of Environmental Research and Public Health·Robert G Poston, Ramendra N Saha
Apr 18, 2020·BMC Genomics·Juan Moriano, Cedric Boeckx
Dec 3, 2020·Cellular and Molecular Life Sciences : CMLS·Britt MossinkNael Nadif Kasri
Oct 27, 2020·Frontiers in Cell and Developmental Biology·Thijs C J VerheulTahsin Stefan Barakat
Dec 10, 2020·International Journal of Molecular Sciences·Sadegheh HaghshenasBekim Sadikovic
Dec 18, 2020·Frontiers in Genetics·Daniel KonzmanJohn A Hanover
Feb 19, 2021·Science Advances·Naihua N GongMatthew S Kayser
May 5, 2021·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Paolo ZanoniAnita Rauch
Dec 15, 2020·Current Opinion in Cell Biology·Hugo B BrandãoAnders S Hansen
Aug 29, 2021·Pharmaceuticals·Marcin JanowskiAleksandra Pękowska
Aug 24, 2021·Trends in Molecular Medicine·Annique Claringbould, Judith B Zaugg
Sep 14, 2021·The FEBS Journal·Katherine M Bonefas, Shigeki Iwase
Nov 23, 2021·Frontiers in Neuroscience·Julia Reichard, Geraldine Zimmer-Bensch

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