The chromatin regulator Brpf1 regulates embryo development and cell proliferation.

The Journal of Biological Chemistry
Linya YouXiang-Jiao Yang

Abstract

With hundreds of chromatin regulators identified in mammals, an emerging issue is how they modulate biological and pathological processes. BRPF1 (bromodomain- and PHD finger-containing protein 1) is a unique chromatin regulator possessing two PHD fingers, one bromodomain and a PWWP domain for recognizing multiple histone modifications. In addition, it binds to the acetyltransferases MOZ, MORF, and HBO1 (also known as KAT6A, KAT6B, and KAT7, respectively) to promote complex formation, restrict substrate specificity, and enhance enzymatic activity. We have recently showed that ablation of the mouse Brpf1 gene causes embryonic lethality at E9.5. Here we present systematic analyses of the mutant animals and demonstrate that the ablation leads to vascular defects in the placenta, yolk sac, and embryo proper, as well as abnormal neural tube closure. At the cellular level, Brpf1 loss inhibits proliferation of embryonic fibroblasts and hematopoietic progenitors. Molecularly, the loss reduces transcription of a ribosomal protein L10 (Rpl10)-like gene and the cell cycle inhibitor p27, and increases expression of the cell-cycle inhibitor p16 and a novel protein homologous to Scp3, a synaptonemal complex protein critical for chromosome ass...Continue Reading

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Citations

Aug 9, 2016·The Journal of Clinical Investigation·Linya YouXiang-Jiao Yang
Oct 24, 2015·Chemical Reviews·Guangtao ZhangMing-Ming Zhou
Oct 21, 2016·Biochimica Et Biophysica Acta·Shuhei IshikuraSenji Shirasawa
Apr 14, 2017·Journal of Medicinal Chemistry·Léa BouchéBernard Haendler
Jun 28, 2019·American Journal of Clinical Pathology·Yan WangYing Liu
Feb 6, 2017·Current Protocols in Protein Science·Nadine PelletierXiang-Jiao Yang
Dec 4, 2019·The Journal of Clinical Investigation·Lin LiXiang-Jiao Yang
Feb 9, 2021·Current Research in Structural Biology·Juliet O ObiKaren C Glass
Aug 28, 2021·Chemistry, an Asian Journal·Soumen BarmanBabu Sudhamalla

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