The chromosomal constitution of embryos arising from monopronuclear oocytes in programmes of assisted reproduction

International Journal of Reproductive Medicine
Bernd E Rosenbusch

Abstract

The assessment of oocytes showing only one pronucleus during assisted reproduction is associated with uncertainty. A compilation of data on the genetic constitution of different developmental stages shows that affected oocytes are able to develop into haploid, diploid, and mosaic embryos with more or less complex chromosomal compositions. In the majority of cases (~80%), haploidy appears to be caused by gynogenesis, whereas parthenogenesis or androgenesis is less common. Most of the diploid embryos result from a fertilization event involving asynchronous formation of the two pronuclei or pronuclear fusion at a very early stage. Uniparental diploidy may sometimes occur if one pronucleus fails to develop and the other pronucleus already contains a diploid genome or alternatively a haploid genome undergoes endoreduplication. In general, the chance of obtaining a biparental diploid embryo appears higher after conventional in vitro fertilization than after intracytoplasmic sperm injection. If a transfer of embryos obtained from monopronuclear oocytes is envisaged, it should be tried to culture them up to the blastocyst since most haploid embryos are not able to reach this stage. Comprehensive counselling of patients on potential ris...Continue Reading

References

Jun 1, 1978·Journal of Medical Genetics·U Mittwoch
Mar 1, 1995·Biology of Reproduction·J LevronJ Cohen
Apr 1, 1994·Human Reproduction·M E JamiesonJ M Connor
May 1, 1993·Journal of Assisted Reproduction and Genetics·S MunnéJ Cohen
Jul 27, 2001·Molecular Reproduction and Development·N Rougier, Z Werb
Mar 5, 2004·Human Reproduction·Edith Suss-TobyJ Itskovitz-Eldor
Feb 12, 2005·Journal of Assisted Reproduction and Genetics·Daniel DasigAmin A Milki
Sep 30, 2006·Human Fertility : Journal of the British Fertility Society·Katie Feenan, Mary Herbert
Oct 24, 2007·Fertility and Sterility·Bernd E Rosenbusch
Nov 7, 2009·Journal of Assisted Reproduction and Genetics·Hongqing LiaoGuangxiu Lu

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Citations

Mar 21, 2020·Zygote : the Biology of Gametes and Early Embryos·Ming LiPing Liu
Sep 5, 2020·Human Fertility : Journal of the British Fertility Society·Lei FuYuan Li
May 13, 2017·Journal of Assisted Reproduction and Genetics·S MateoM Boada
Mar 11, 2021·Theriogenology·Ryosuke SuzukiSatoshi Sugimura
Jul 31, 2021·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Lei FuYuan Li
Nov 14, 2021·Proceedings of the National Academy of Sciences of the United States of America·Daniel AriadRajiv C McCoy

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Methods Mentioned

BETA
PCR
chromosomal aberration

Software Mentioned

Scopus

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