The chromosomal passenger complex (CPC) as a key orchestrator of orderly mitotic exit and cytokinesis

Frontiers in Cell and Developmental Biology
Mayumi Kitagawa, Sang Hyun Lee

Abstract

Understanding the molecular network of orderly mitotic exit to re-establish a functional interphase nucleus is critical because disordered mitotic exit inevitably leads to genomic instability. In contrast to the mechanisms of the entrance to mitosis, however, little is known about what controls the orderly exit from mitosis, particularly in mammalian cells. The chromosomal passenger complex (CPC), which is composed of Aurora B, INCENP, Borealin and Survivin, is one of the most widely studied and highly conserved hetero-tetrameric complexes. The CPC orchestrates proper chromosome segregation with cytokinesis by targeting to specific locations at different stages of mitosis. Recent studies reveal that controlling CPC localization and Aurora B kinase activity also serves as a key surveillance mechanism for the orderly mitotic exit. This ensures the reformation of a functional interphase nucleus from condensed mitotic chromosomes by delaying mitotic exit and cytokinetic processes in response to defects in chromosome segregation. In this review, we will summarize the latest insight into the molecular mechanisms that regulate CPC localization during mitotic exit and discuss how targeting Aurora B activity to different locations at di...Continue Reading

References

Mar 1, 1991·Chromosoma·W C Earnshaw, R L Bernat
Nov 4, 2000·The EMBO Journal·E HillF A Barr
Sep 14, 2001·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·J MorishitaM Yanagida
Jun 26, 2002·The Journal of Cell Biology·Cristiana MollinariRobert L Margolis
Aug 20, 2003·Molecular Biology of the Cell·Reiko HondaErich A Nigg
Nov 8, 2003·Science·Gislene Pereira, Elmar Schiebel
May 18, 2004·Molecular Biology of the Cell·Takao OnoTatsuya Hirano
Jul 14, 2004·The Journal of Cell Biology·Reto GassmannWilliam C Earnshaw
Apr 28, 2005·Current Biology : CB·Annika GuseMichael Glotzer
Dec 27, 2005·Nature Cell Biology·Hidemasa GotoMasaki Inagaki
Sep 26, 2006·Nature Cell Biology·Paola VagnarelliWilliam C Earnshaw
Mar 16, 2007·Journal of Cell Science·Jesse J LippJan-Michael Peters
Mar 30, 2007·Nucleic Acids Research·Ai TakemotoKeiji Kimura
Jun 15, 2007·Nature Cell Biology·Felipe Mora-BermúdezJan Ellenberg
Dec 14, 2007·The Biochemical Journal·Joseph D DukesPaul Whitley
Mar 5, 2008·The Journal of Cell Biology·Elisa DultzJan Ellenberg
Mar 26, 2008·The Journal of Cell Biology·Norihiko NakazawaMitsuhiro Yanagida
Apr 16, 2008·The Journal of Cell Biology·Chi-Kuo HuTimothy J Mitchison

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Citations

Oct 2, 2015·Journal of Molecular Biology·Anna Katharina SchellhausWolfram Antonin
Mar 22, 2016·Clinical and Experimental Pharmacology & Physiology·Cameron T DurlacherShu-Feng Zhou
Jun 30, 2016·Cell Cycle·Alberto M Luciano, John J Peluso
Jun 30, 2016·Nature Reviews. Molecular Cell Biology·Nitya Ramkumar, Buzz Baum
Jun 25, 2016·Cancer Cell International·Himani GargShweta Dubey
Jul 5, 2016·Chromosoma·Harsh Nagpal, Tatsuo Fukagawa
Oct 21, 2016·Medicinal Research Reviews·Min YanQuentin Liu
Apr 14, 2016·PloS One·Kimberly N WeiderholdLi-Yuan Yu-Lee
Apr 25, 2017·Oncogene·G CombesS Elowe
Aug 28, 2015·Molecular Biology of the Cell·Christine M FieldTimothy J Mitchison
Jan 15, 2016·Molecular Biology of the Cell·Ryota UeharaGohta Goshima
Feb 21, 2018·Frontiers in Cell and Developmental Biology·Julie P I Welburn, A Arockia Jeyaprakash
Dec 6, 2017·Nature Communications·Nicolas TauletBenedicte Delaval
Jan 7, 2017·Scientific Reports·Francisco Abadía-MolinaAlex MacKenzie
Jul 9, 2016·Nature Communications·Midori ShimadaMakoto Nakanishi
May 8, 2019·Journal of Cellular Physiology·Parisa ZafariMahdi Taghadosi
Apr 16, 2020·Acta Neuropathologica Communications·Alexander SosunovJames E Goldman
Dec 12, 2018·Nature Reviews. Cancer·Susanne M A Lens, René H Medema
Jun 25, 2016·Cell Cycle·Jayasha ShandilyaStefan G E Roberts
May 12, 2017·FEBS Letters·Caroline A JohnsonH Troy Ghashghaei
Sep 22, 2017·Cell Cycle·Stephanie Link, Sandra B Hake
Oct 17, 2019·International Journal of Molecular Sciences·Lauana Greicy Tonon LemosRaquel Ciuvalschi Maia
Nov 19, 2015·Frontiers in Oncology·Pauline HascoetYannick Arlot-Bonnemains
Oct 14, 2020·Cell Biology International·S Daisy PrecillaAnitha Thirugnanasambandhar Sivasubramanian
Jun 5, 2017·Drug Discovery Today·Robert C PeeryJian-Ting Zhang
Oct 17, 2020·Journal of Molecular Biology·Harsh Nagpal, Beat Fierz
Mar 18, 2021·Seminars in Cancer Biology·Halina WasClaudine Kieda
Jun 26, 2020·Pharmacology & Therapeutics·Swati KumarRichard C Turkington
Oct 12, 2020·Advances in Biological Regulation·Peter J Parker Silvia Martini
Apr 27, 2021·Experimental Biology and Medicine·Yiting QiaoJianxiang Chen
Aug 19, 2021·Journal of Cellular Physiology·Siao Muk ChengChun Hei Antonio Cheung
Oct 16, 2021·Frontiers in Cell and Developmental Biology·Marina Rodriguez-MuñozTeresa Anglada

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Methods Mentioned

BETA
genetic knockout
Ubiquitination
immunodepletion
GTPase
xenografts

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