The chromosome 7q region association with rheumatoid arthritis in females in a British population is not replicated in a North American case-control series.

Arthritis and Rheumatism
Benjamin D KormanElaine F Remmers

Abstract

The single-nucleotide polymorphism (SNP) rs11761231 on chromosome 7q has been reported to be sexually dimorphic marker for rheumatoid arthritis (RA) susceptibility in a British population. We sought to replicate this finding and to better characterize susceptibility alleles in the region in a North American population. DNA from 2 North American collections of RA patients and controls (1,605 cases and 2,640 controls) was genotyped for rs11761231 and 16 additional chromosome 7q tag SNPs using Sequenom iPlex assays. Association tests were performed for each collection and also separately, contrasting male cases with male controls and female cases with female controls. Principal components analysis (EigenStrat) was used to determine association with RA before and after adjusting for population stratification in the subset of the samples for which there were whole-genome SNP data (772 cases and 1,213 controls). We failed to replicate an association of the 7q region with RA. Initially, rs11761231 showed evidence for association with RA in the North American Rheumatoid Arthritis Consortium (NARAC) collection (P=0.0073), and rs11765576 showed association with RA in both the NARAC (P=0.038) and RA replication (P = 0.0013) collections. T...Continue Reading

References

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Citations

Mar 24, 2009·Annual Review of Immunology·Peter K Gregersen, Lina M Olsson
Aug 18, 2009·Journal of Autoimmunity·Pietro Invernizzi, M Eric Gershwin
Nov 3, 2017·The Journal of Rheumatology·Elena SánchezUNKNOWN GENAR Study
Jun 11, 2010·Journal of Neuro-oncology·Katarzyna KoslaAndrzej K Bednarek
Jun 17, 2011·Journal of Human Genetics·Chee-Seng KuAgus Salim
Sep 19, 2014·Cellular and Molecular Life Sciences : CMLS·Larissa Savelyeva, Lena M Brueckner
Sep 28, 2018·Clinical & Experimental Ophthalmology·Vannessa LeungTimothy V Roberts
Jun 13, 2020·Clinical Anatomy : Official Journal of the American Association of Clinical Anatomists & the British Association of Clinical Anatomists·John C Merriam, Daniel S Casper

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