The cilium as a force sensor-myth versus reality

Journal of Cell Science
Rita R FerreiraJulien Vermot

Abstract

Cells need to sense their mechanical environment during the growth of developing tissues and maintenance of adult tissues. The concept of force-sensing mechanisms that act through cell-cell and cell-matrix adhesions is now well established and accepted. Additionally, it is widely believed that force sensing can be mediated through cilia. Yet, this hypothesis is still debated. By using primary cilia sensing as a paradigm, we describe the physical requirements for cilium-mediated mechanical sensing and discuss the different hypotheses of how this could work. We review the different mechanosensitive channels within the cilium, their potential mode of action and their biological implications. In addition, we describe the biological contexts in which cilia are acting - in particular, the left-right organizer - and discuss the challenges to discriminate between cilium-mediated chemosensitivity and mechanosensitivity. Throughout, we provide perspectives on how quantitative analysis and physics-based arguments might help to better understand the biological mechanisms by which cells use cilia to probe their mechanical environment.

References

Oct 30, 1998·Biochemical and Biophysical Research Communications·S C ParnellJ P Calvet
Nov 1, 2001·The Journal of Membrane Biology·H A Praetorius, K R Spring
Mar 26, 2002·The Journal of Biological Chemistry·Stephen C ParnellJames P Calvet
Jul 5, 2002·Nature·Jeffrey J EssnerMartina Brueckner
Sep 20, 2002·Journal of the American Society of Nephrology : JASN·Bradley K YoderLisa M Guay-Woodford
Nov 5, 2002·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Theo H SmitJacques M Huyghe
Jan 18, 2003·The Journal of Membrane Biology·H A Praetorius, K R Spring
Mar 7, 2003·Lancet·Albert C M Ong, Denys N Wheatley
Apr 22, 2003·Journal of Cellular Biochemistry·James F Whitfield
Aug 16, 2003·Current Opinion in Nephrology and Hypertension·Helle A Praetorius, Kenneth R Spring
Feb 27, 2004·Cell Biology International·Henry MagloireFrançoise Bleicher
Feb 27, 2004·Cell Biology International·C G JensenS S Bowser
Jan 25, 2005·Nature Cell Biology·Rosario MarotoOwen P Hamill
Sep 8, 2005·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Kim Van der HeidenRobert E Poelmann
Feb 8, 2006·Annual Review of Physiology·I Scott RamseyDavid E Clapham
Mar 28, 2006·Journal of the American Society of Nephrology : JASN·Surya M NauliJing Zhou
May 3, 2006·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Susan R McGlashanC Anthony Poole
Jun 29, 2006·Bulletin of Mathematical Biology·D J SmithJ R Blake
Jun 21, 2007·Annual Review of Biochemistry·Kartik Venkatachalam, Craig Montell
Aug 4, 2007·Proceedings of the National Academy of Sciences of the United States of America·Amanda M D MaloneChristopher R Jacobs
Nov 21, 2007·Proceedings of the National Academy of Sciences of the United States of America·Sergio A GradiloneNicholas F Larusso
Feb 26, 2008·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Beerend P HierckRobert E Poelmann
Jun 17, 2008·Biophysical Journal·Willy SupattoJulien Vermot
Aug 13, 2008·The Journal of Cell Biology·Michael KöttgenGerd Walz
Sep 3, 2008·Cell Metabolism·Ritsuko MasuyamaGeert Carmeliet
Dec 6, 2008·Seminars in Cell & Developmental Biology·Martin BlumPhilipp Vick
Jul 16, 2009·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Eve DonnellyCornelia Farnum
Jan 22, 2010·American Journal of Physiology. Renal Physiology·Susanna RydholmHjalmar Brismar
Aug 5, 2010·Biophysical Journal·Andrew P StewartJ Michael Edwardson
Feb 11, 2011·Development·Sarah FieldDominic P Norris

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Citations

Dec 12, 2019·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Adam E Cohen, Zheng Shi
Dec 31, 2019·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Kirsty Y Wan, Gáspár Jékely
Dec 31, 2019·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Julyan H E CartwrightIdan Tuval
Dec 31, 2019·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Luis Alberto Bezares-CalderónGáspár Jékely
Dec 31, 2019·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Christa RingersNathalie Jurisch-Yaksi
Dec 31, 2019·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·M T GallagherD J Smith
Oct 31, 2019·Tissue Engineering. Part B, Reviews·Aleena A Saidova, Ivan A Vorobjev
Mar 14, 2020·Biomolecules·Marietta HerrmannFranz Jakob
Apr 30, 2020·The Journal of Cell Biology·Peiwei LiuKarl Lechtreck
Aug 10, 2020·Development·Margo DaemsElizabeth A V Jones
Oct 20, 2020·Frontiers in Cell and Developmental Biology·Benjamin VitreBenedicte Delaval
Jun 17, 2020·Seminars in Cell & Developmental Biology·Daniel KopinkeSaikat Mukhopadhyay
Jun 24, 2020·Seminars in Cell & Developmental Biology·Rosie B Little, Dominic P Norris
Dec 16, 2020·Developmental Cell·Katharine Goodwin, Celeste M Nelson
Oct 24, 2020·Current Stem Cell Reports·Paulina D HortonPamela L Wenzel
Jan 15, 2021·Journal of Cell Science·Oscar M J A StassenCecilia M Sahlgren
Jun 8, 2021·Frontiers in Cell and Developmental Biology·Wei WangPamela V Tran
Aug 5, 2021·ELife·David HickeyRamin Golestanian
Aug 26, 2021·Open Biology·Yuhei NishimuraMasaki Inagaki
Sep 2, 2021·Advances in Wound Care·Shamik MascharakMichael T Longaker
Sep 3, 2021·Journal of Cell Science·Aurore Claude-TaupinNicolas Dupont
Dec 5, 2021·Nature Reviews. Cardiology·Lydia DjenouneShiaulou Yuan

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