PMID: 1184311Oct 1, 1975Paper

The circadian rhythm of the intraocular pressure in the New Zealand White rabbit.

Investigative Ophthalmology
R S KatzE D Weitzman

Abstract

Most physiologic functions in man as well as in animals have been shown to have a circadian (approximately 24 hour) rhythm. It has been found in both the normal and glaucomatous human eye that the intraocular pressure, which is one of these circadian functions, varies considerably over a 24-hour period. Because of the extensive use of the rabbit in glaucoma research, a detailed study of the intraocular pressure over a 24-hour period was undertaken. Using hourly applanation tonometry for 25 consecutive measurements in ten New Zealand White rabbits (20 eyes), a circadian rhythm of the rabbit intraocular pressure was found. The pressures were lowest at night and rose to their highest values during the day. In addition, the data suggest that the maximum intraocular pressure may be biphasic with maximum values occurring between 0800 and 1100 and 1600 and 1900. Therefore, studies involving the New Zealand White rabbit must take into consideration these 24-hour pressure changes when intraocular pressure measurements are made.

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.