PMID: 3755657Apr 1, 1986Paper

The circadian variation of thyrotrophin in patients with primary thyroidal disease

Clinical Endocrinology
P J EvansM F Scanlon

Abstract

We have used a highly sensitive immunochemiluminometric assay (ICMA) for human TSH to study the effect of thyroid status on the circadian variation in TSH levels. Three subjects with Graves' disease, three with toxic multinodular goitre and three with euthyroid multinodular goitre were sampled every hour for 24 h. The results obtained were compared to those from five euthyroid control subjects. It was found that some patients with hyperthyroidism and suppressed basal TSH levels exhibited a 24 h secretory pattern similar to that seen in normal subjects with peak TSH levels occurring at night. In addition two subjects with a euthyroid multinodular goitre demonstrated levels of TSH below the normal range despite being clinically and biochemically euthyroid. TSH suppression in these subjects is probably related to some degree of thyroid autonomy and possible development of hyperthyroidism in the future.

References

Jul 1, 1976·The Journal of Clinical Endocrinology and Metabolism·J Weeke, P Laurberg
Aug 1, 1972·The Journal of Clinical Investigation·P J Snyder, R D Utiger
May 1, 1973·Scandinavian Journal of Clinical and Laboratory Investigation·J Weeke
Apr 1, 1984·Clinical Endocrinology·I WeeksJ S Woodhead

❮ Previous
Next ❯

Citations

Mar 18, 1997·Clinica Chimica Acta; International Journal of Clinical Chemistry·A K RasmussenU Feldt-Rasmussen
Aug 1, 1988·Baillière's Clinical Endocrinology and Metabolism·P J Leslie, A D Toft
Dec 4, 2003·Thyroid : Official Journal of the American Thyroid Association·Stig AndersenPeter Laurberg
Feb 24, 2001·Thyroid : Official Journal of the American Thyroid Association·B HirshbergN J Sarlis
Nov 1, 1993·Paraplegia·C H TatorD F Andrews
Mar 1, 1993·Paraplegia·P S BeraldoM R Alencar
Apr 12, 2013·Endocrine Reviews·Ferdinand Roelfsema, Johannes D Veldhuis
Jan 1, 1988·Chronobiology International·J SalvadorM F Scanlon

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.