PMID: 9537357Apr 16, 1998Paper

The CIRCE element and its putative repressor control cell cycle expression of the Caulobacter crescentus groESL operon

Journal of Bacteriology
Regina L BaldiniS L Gomes

Abstract

The groESL operon is under complex regulation in Caulobacter crescentus. In addition to strong induction after exposure to heat shock, under physiological growth conditions, its expression is subject to cell cycle control. Transcription and translation of the groE genes occur primarily in predivisional cells, with very low levels of expression in stalked cells. The regulatory region of groESL contains both a sigma32-like promoter and a CIRCE element. Overexpression of C. crescentus sigma32 gives rise to higher levels of GroEL and increased levels of the groESL transcript coming from the sigma32-like promoter. Site-directed mutagenesis in CIRCE has indicated a negative role for this cis-acting element in the expression of groESL only at normal growth temperatures, with a minor effect on heat shock induction. Furthermore, groESL-lacZ transcription fusions carrying mutations in CIRCE are no longer cell cycle regulated. Analysis of an hrcA null strain, carrying a disruption in the gene encoding the putative repressor that binds to the CIRCE element, shows constitutive synthesis of GroEL throughout the Caulobacter cell cycle. These results indicate a negative role for the hrcA gene product and the CIRCE element in the temporal contr...Continue Reading

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Citations

Sep 2, 2010·Microbiology and Molecular Biology Reviews : MMBR·Ju-Hoon Lee, Daniel J O'Sullivan
Feb 13, 1999·Molecular Microbiology·F Narberhaus
Dec 30, 1999·Journal of Bacteriology·A C MinderF Narberhaus
Feb 22, 2005·Molecular Microbiology·Amy K SchmidMary E Lidstrom
Jul 27, 2002·Annual Review of Microbiology·Gregory T Marczynski, Lucy Shapiro
Jun 6, 2003·Applied and Environmental Microbiology·Luiz Fernando G ZuletaMarilis V Marques
May 6, 2004·Journal of Bacteriology·Audrey Bellier, Philippe Mazodier
Oct 7, 2004·Journal of Bacteriology·Michelle F SusinSuely L Gomes
May 18, 2021·Frontiers in Molecular Biosciences·Kristen Schroeder, Kristina Jonas

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