The circular RNA circ-ITCH suppresses ovarian carcinoma progression through targeting miR-145/RASA1 signaling

Biochemical and Biophysical Research Communications
Jinghui HuYouguo Chen

Abstract

As the leading cause of death for gynecological cancers, ovarian cancer (OC) ranks fifth overall for cancer-related death among women. Emerging evidence has indicated that circular RNA (circRNA), recognized as functional non-coding transcripts in eukaryotic cells, may be involved in many physiological or pathological processes. It was reported that circ-ITCH is downregulated in multi cancers and serves as a powerful tumor suppressor among through a competing endogenous RNA (ceRNA) pathway. However, the existence and the role of circ-ITCH in OC was not reported. Here, we found a broad down-regulation of circ-ITCH in OC tissues and cells, which correlates with a worse prognosis in OC patients. Functional studies suggest that circ-ITCH overexpression inhibits the cell viability and motility by CCK8, cell cycle, wound healing assay and invasion assay. It also inhibits the tumorigenesis ability in xenograft NOD mice in vivo. Mechanically, we demonstrated that circ-TCH acts as a ceRNA to sponge miR-145, increases the level of RASA1, and inhibits the malignant progression of OC cells via the circ-ITCH-miR-145-RASA1 axis in vitro and in vivo. Taken together, our findings provide a novel tumor suppressive role regarding circ-ITCH functi...Continue Reading

Citations

Apr 28, 2019·Journal of Biomedical Science·Chun-Ying Yu, Hung-Chih Kuo
May 21, 2019·The International Journal of Biological Markers·Yunfang HuangFang Xu
Aug 8, 2019·Artificial Cells, Nanomedicine, and Biotechnology·Chongmin RenBin Yue
Sep 5, 2019·Journal of Ovarian Research·Zahra ShabaninejadHamed Mirzaei
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Oct 17, 2020·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Jason R Brown, Arul M Chinnaiyan
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Sep 25, 2021·Cellular & Molecular Biology Letters·Zahra ForuzandehMohammad Reza Alivand
Oct 29, 2021·Environmental Science and Pollution Research International·Hui WangHeng Wang

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