The circulating form of neprilysin is not a general biomarker for overall survival in treatment-naïve cancer patients

Scientific Reports
Noemi PavoMartin Hülsmann

Abstract

The transmembrane zink-metalloendopeptidase neprilysin (NEP) is implicated in cardiovascular disease but also tumor biology. The aim of the study was to investigate the relationship of circulating NEP (cNEP) levels with established cardiovascular biomarkers and its effect on overall survival in an unselected cohort of treatment-naïve cancer patients. 555 consecutive cancer patients prior anticancer therapy were enrolled prospectively. NEP levels were determined alongside routine laboratory parameters, established cardiac biomarkers, i.e. NT-proBNP, hsTnT, MR-proANP, MR-proADM, CT-proET-1 and Copeptin, and inflammatory parameters, i.e. CRP, IL-6 and SAA, in venous plasma samples. All-cause mortality was the primary endpoint. cNEP levels of 276 pg/ml (IQR: 0-5981) displayed a weak inverse correlation with age [r = -0.12, p = 0.023] and inflammatory status [r = -0.14, p = 0.007 CRP; r = -0.20, p < 0.001 IL-6 and r = -0.18, p < 0.001 SAA]. cNEP was comparable between different tumor entities and stages and not related to functional parameters of other organ systems as kidney, liver or especially the heart. Moreover, cNEP was not associated with overall survival in the total cohort [adj.HR for ln (cNEP) 1.00, 95% CI: 0.94-1.06, p = ...Continue Reading

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Citations

Sep 19, 2019·Toxicology Mechanisms and Methods·Runali SankheMadhavan Nampoothiri
May 20, 2020·Journal of the American Heart Association·Suriya PrausmüllerMartin Hülsmann
Feb 6, 2020·International Journal of Molecular Sciences·Elisa WeißUrsula Hiden
Sep 19, 2020·Cardiac Failure Review·Noemi PavoMartin Hülsmann
May 30, 2020·Biochemical Pharmacology·Manar Mohammed El Tabaa, Maram Mohammed El Tabaa
Jul 3, 2021·Frontiers in Cardiovascular Medicine·Hyeon Seok HwangKyung Hwan Jeong
Nov 9, 2020·European Journal of Pharmacology·Runali SankheAnoop Kishore

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
ELISA
FACS

Software Mentioned

SPSS

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