The circulating level of interleukins 6 and 18 in ischemic and idiopathic dilated cardiomyopathy

Journal of Cardiovascular and Thoracic Research
Mahdiyar Iravani SaadiRamin Yaghoobi

Abstract

Introduction: By aging population, the heart failure and its life-threatening complications have become an enormous issue in public health. Regarding the inflammation as a major contributing pathological factor, the determination of most important inflammatory targets for immunomodulation is a problematic puzzle in the treatment of heart failure patients and the inflammatory pathways primarily involved in different underlying conditions contributing to heart failure can be an area which is worthy of focused research. Considering the dilated cardiomyopathy (DCM) as a relatively high-incident disease leading to heart failure, the aim of this study is to determine the difference in the expression level of interleukin (IL)-6 and IL-18 in patients with ischemic and idiopathic DCM. Methods: 39 non-diabetic patients with ischemic and 37 ones with idiopathic DCM were enrolled in the study. 48 healthy individuals were also considered as control group. For quantitative determination of the mRNA expression level of IL-6 and IL-18 genes, an in-house- SYBR Green real-time PCR was used and Glyceraldehyde 3-phosphate dehydrogenase (GAPDH) was considered as internal control gene. The left ventricular end-diastolic volume (LVEDV) and left ve...Continue Reading

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Citations

May 4, 2021·Frontiers in Cardiovascular Medicine·Ayat KadhiGeorges Nemer

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Methods Mentioned

BETA
PCR

Software Mentioned

SPSS

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