The circulating level of Non-coding RNA for breast cancer diagnosis

miao wanghuijian wu


Background: The expression of non-coding RNAs were closely related to breast cancer progression. However, there were no systemic analysis of non-coding RNAs in breast cancer diagnosis of the blood circulatory system. Herein, we aimed to collect all the evidence to test the potential role of non-coding RNAs as novel biomarkers in human breast cancers. Methods: A comprehensive search strategy was used to search relevant literatures in the Web of Science, PubMed, and Embase databases from January 2012 to November 2019. The correlation of non-coding RNAs expression in serum, plasma or blood circulatory system and the diagnostic accuracy of BC markers were analyzed. The methodological quality of each study was assessed using the QUADAS-2. Statistical analysis was used the STATA (version 12.0), Meta-Disc (version 1.4) and Review Manager (version 5.3) software. Results: The present meta-analysis of the non-coding RNAs expression data of BC patients and healthy specimens’ bloodfrom 2392 patients in 24 publications (32 studies). The pooled sensitivity, specificity, and AUC values were 0.82, 0.83, and 0.89, respectively. Subgroup analyses showed that the expression of non-coding RNA (miRNA, circRNA, andlncRNA) in the blood circulatory sy...Continue Reading

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