The Circulating Level of Soluble Receptor for Advanced Glycation End Products Displays Different Patterns in Ulcerative Colitis and Crohn's Disease: A Cross-Sectional Study

Digestive Diseases and Sciences
Rachele CiccocioppoGino Roberto Corazza

Abstract

RAGE is a transmembrane receptor expressed on immune and endothelial cells, whose binding with its ligands, the S100 calgranulins, leads to chronic inflammation. Conversely, its soluble form (sRAGE) plays a protective role by acting as a decoy. We carried out a cross-sectional analysis of the sRAGE and S100A12 serum levels in patients with Crohn's disease (CD) and ulcerative colitis (UC) and searched for a correlation with clinical and biological markers of activity. We enrolled 60 CD, 67 UC patients, and 66 controls (all adults). Disease activity was scored through the clinical, endoscopic, and histologic indexes of severity, whilst disease location and behaviour were assessed according to the Montreal classification. In all cases, the levels of serum sRAGE, S100A12, C-reactive protein, and faecal calprotectin were measured. sRAGE levels were significantly lower in UC, both active and inactive, than in controls and CD (817.35, range 437.3-1449; 1211, range 843.7-1618; 1207.5, range 743.15-1875.75; P < 0.05 for both), and inversely correlated with clinical and endoscopic indexes of activity in both IBD groups (P < 0.05 for all) and with the histologic score in the CD group. Moreover, those CD patients with a penetrating behavio...Continue Reading

References

Oct 15, 1998·Gut·R S WalmsleyR N Allan
Dec 8, 2000·Biochimica Et Biophysica Acta·A M SchmidtD M Stern
Oct 3, 2001·The Journal of Clinical Investigation·A M SchmidtD M Stern
May 10, 2005·QJM : Monthly Journal of the Association of Physicians·D R GayaJ F Mackenzie
May 9, 2006·Gastroenterology·George F LongstrethRobin C Spiller
Feb 6, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ke ZenYuan Liu
Jul 3, 2007·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·M J W MeijerH W Verspaget
Jan 8, 2008·World Journal of Gastroenterology : WJG·Jun-Ying XiangNan-Ping Xiao
Apr 30, 2008·Amino Acids·Jens Pietzsch, Susan Hoppmann
Jul 4, 2008·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Giuseppe Danilo NorataAlberico Luigi Catapano
Mar 12, 2009·Current Medicinal Chemistry·Francesca SantilliGiovanni Davì
May 21, 2009·Journal of Leukocyte Biology·Shaival H DavéScott E Plevy
May 26, 2009·Neurobiology of Aging·Velandai SrikanthGerald Münch
May 30, 2009·Journal of Leukocyte Biology·Ravichandran RamasamyAnn Marie Schmidt
Nov 20, 2009·The New England Journal of Medicine·Clara Abraham, Judy H Cho
Mar 3, 2010·Annual Review of Immunology·Gary P SimsAnthony J Coyle
Oct 16, 2010·BMC Gastroenterology·Anastassios C ManolakisSpyros P Potamianos
Dec 3, 2010·Journal of Crohn's & Colitis·Gert Van AsscheUNKNOWN European Crohn's and Colitis Organisation (ECCO)
Mar 1, 2008·Journal of Crohn's & Colitis·E F StangeUNKNOWN European Crohn's and Colitis Organisation (ECCO)
Feb 12, 2011·American Journal of Physiology. Gastrointestinal and Liver Physiology·Jan DäbritzDirk Foell
Jan 4, 2012·Annals of the New York Academy of Sciences·Ravichandran RamasamyAnn Marie Schmidt
Feb 5, 2013·Inflammatory Bowel Diseases·Jan DäbritzDirk Foell
Dec 24, 2013·World Journal of Gastroenterology : WJG·Rachele CiccocioppoGino Roberto Corazza

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Citations

Sep 15, 2017·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Romy M Heilmann, Karin Allenspach
Jul 28, 2020·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Angela Isabel Cabrera-GarcíaRomy M Heilmann
Mar 24, 2016·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·Salih BogaCanan Alkim
Mar 5, 2016·Mucosal Immunology·R K BoyapatiG-T Ho
Sep 10, 2019·European Journal of Gastroenterology & Hepatology·P KourkoulisM Gazouli
Sep 18, 2020·Nutrients·Timme van der LugtMisha F Vrolijk
Nov 15, 2020·The Veterinary Clinics of North America. Small Animal Practice·Juan Hernandez, Julien Rodolphe Samuel Dandrieux

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