The Circulating Levels of Selenium, Zinc, Midkine, Some Inflammatory Cytokines, and Angiogenic Factors in Mitral Chordae Tendineae Rupture

Biological Trace Element Research
Birsen AydemirSelim Ogut

Abstract

Chordae tendineae rupture process is associated with increased production of inflammatory and angiogenesis mediators in connective tissues, which contributes to chronic inflammation and pathogenesis of degenerative chordae. A few trace elements are known to possess antioxidant, anti-inflammatory, and antiangiogenic properties. Therefore, the aim of this study was to determine whether zinc, selenium, midkine (MK), interleukin-1β (IL-1β), interleukin-6 (IL-6), interleukin-8 (IL-8), tumor necrosis factor-alpha (TNF-α), vascular endothelial growth factor-A (VEGF-A), platelet-derived growth factor-BB (PDGF-BB), and reduced glutathione (GSH) levels are associated with inflammation and angiogenesis processes in the context of a potential etiology causing aggravation of mitral regurgitation and/or ruptured chordae tendineae. Seventy-one subjects comprising 34 patients with mitral chordae tendineae rupture (MCTR) and 37 healthy controls diagnosed on the basis of their clinical profile and transthoracic echocardiography were included in this study. The levels of GSH, MK, selenium, and zinc were found to be lower in the patients group when compared to control group. There were no significant difference in plasma TNF-α, IL-1β, IL-6, IL-8, ...Continue Reading

References

Dec 17, 2004·Pharmacological Reviews·Ann HoebenErnst A De Bruijn
Jul 7, 2005·Scandinavian Journal of Medicine & Science in Sports·T PufeB N Tillmann
Feb 7, 2006·European Journal of Echocardiography : the Journal of the Working Group on Echocardiography of the European Society of Cardiology·Roberto M LangUNKNOWN European Association of Echocardiography, European Society of Cardiology
Apr 24, 2007·The Journal of Nutrition·Ananda S Prasad
Feb 27, 2008·Journal of Clinical Biochemistry and Nutrition·Tomoko JohtatsuMasaya Sasaki
Oct 22, 2008·Circulation·Jun Yoshioka, Richard T Lee
Feb 21, 2009·The Journal of Rheumatology·Laura K HummersMichael Simons
May 26, 2010·Human & Experimental Toxicology·Nuray YazihanAhmet Sayal
Jul 2, 2010·Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis·Chih-Hung GuoTe-Cheng Yang
Aug 28, 2010·Biological Trace Element Research·Suleyman ÖnalManuel F Flores-Arce
Jun 19, 2012·American Journal of Physiology. Heart and Circulatory Physiology·Ludwig T WeckbachBarbara Walzog
Jul 24, 2012·Biological Trace Element Research·Mustafa NazıroğluManuel Flores-Arce
Feb 23, 2013·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Young-Woong KimTatiana V Byzova
Sep 10, 2014·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Ananda S Prasad

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Jun 30, 2019·Nutrients·Sohayla A Z IbrahimAbdelali Agouni

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