The Clarithromycin Susceptibility Genotype Affects the Treatment Outcome of Patients with Mycobacterium abscessus Lung Disease

Antimicrobial Agents and Chemotherapy
Qi GuoFangyou Yu

Abstract

Mycobacterium abscessus accounts for a large proportion of lung disease cases caused by rapidly growing mycobacteria. The association between clarithromycin sensitivity and treatment outcome is clear. However, M. abscessus culture and antibiotic susceptibility testing are time-consuming. Clarithromycin susceptibility genotyping offers an alternate, rapid approach to predicting the efficacy of clarithromycin-based antibiotic therapy. M. abscessus lung disease patients were divided into two groups based upon the clarithromycin susceptibility genotype of the organism isolated. A retrospective analysis was conducted to compare the clinical features, microbiological characteristics, and treatment outcomes of the two groups. Several other potential predictors of the response to treatment were also assessed. Sixty-nine patients were enrolled in the clarithromycin-resistant genotype group, which included 5 infected with rrl 2058-2059 mutants and 64 infected with erm(41)T28-type M. abscessus; 31 were in the clarithromycin-sensitive group, i.e., 6 and 25 patients infected with genotypes erm(41)C28 and erm(41) M type, respectively. The results showed that lung disease patients infected with clarithromycin-sensitive and -resistant M. absce...Continue Reading

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Citations

Mar 17, 2020·The Journal of Infectious Diseases·Bing LiHaiqing Chu
Jun 27, 2019·The Journal of Antimicrobial Chemotherapy·Hannelore I BaxJurriaan E M de Steenwinkel
Sep 3, 2020·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Keiji FujiwaraKozo Morimoto
Apr 29, 2021·Journal of Medical Microbiology·Amanda BordinDavid M Whiley
Jun 8, 2021·Antimicrobial Agents and Chemotherapy·Qi GuoHaiqing Chu

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Datasets Mentioned

BETA
PRJNA398137

Methods Mentioned

BETA
genotyping
bronchoalveolar
lavage
PCR

Software Mentioned

QUAST
SPSS20
BLAST
SPAdes

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