The class A macrophage scavenger receptor is a major pattern recognition receptor for Neisseria meningitidis which is independent of lipopolysaccharide and not required for secretory responses.

Infection and Immunity
Leanne PeiserSiamon Gordon

Abstract

Macrophages (Mphi) play a key role in the pathogenesis of invasive meningococcal infections. The roles of two pattern recognition molecules, the Mphi scavenger receptor (SR-A) and Toll-like receptor 4 (TLR-4), have been investigated using bone marrow culture-derived Mphi (BMMphi). Surprisingly, a comparison of BMMphi from wild-type and SR-A knockout (SR-A(-/-)) mice showed that nonopsonic phagocytosis of meningococci was mediated almost exclusively via SR-A. Previous studies have demonstrated only a partial involvement of the receptor in the uptake of other bacteria, such as Escherichia coli. Interestingly, we also show that lipopolysaccharide (LPS) was not the ligand for the receptor on these organisms. Further study of the downstream events of SR-A-mediated ingestion of Neisseria meningitidis demonstrated that SR-A was not required for cytokine production. To determine the bacterial and host factors required to stimulate Mphi activation, we examined TLR-4-deficient Mphi from C3H/HeJ mice and LPS-deficient meningococci. TLR-4-deficient cells elaborated reduced amounts of tumor necrosis factor alpha, interleukin-12 (IL-12), and IL-10, even though ingestion via SR-A was unaffected in these cells. Similarly, although there was no...Continue Reading

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Citations

Nov 16, 2011·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Huanfa YiXiang-Yang Wang
Mar 27, 2007·Nature Reviews. Cancer·Angelo M De MarzoWilliam G Nelson
Apr 5, 2005·Nature Reviews. Microbiology·Martijn F B G GebbinkHan A B Wösten
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Mar 18, 2005·Annual Review of Immunology·P R TaylorS Gordon
Jun 6, 2012·International Journal of Alzheimer's Disease·Kim Wilkinson, Joseph El Khoury
May 6, 2006·American Journal of Respiratory Cell and Molecular Biology·Mohamed S ArredouaniLester Kobzik
Dec 15, 2006·Proceedings of the National Academy of Sciences of the United States of America·Tracie A SeimonIra Tabas
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May 19, 2009·Molecular Immunology·Haiqi HeMichael H Kogut
Nov 21, 2007·Microbes and Infection·D M E BowdishS Gordon
Jul 24, 2004·Immunology·Subhankar MukhopadhyaySiamon Gordon
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Apr 25, 2009·Cellular Microbiology·Thomas Areschoug, Siamon Gordon
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Feb 26, 2011·Immunological Reviews·Annette PlüddemannSiamon Gordon
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Dec 15, 2004·Microbes and Infection·David M Underhill, Benjamin Gantner
Oct 16, 2004·Immunobiology·Subhankar Mukhopadhyay, Siamon Gordon
Nov 13, 2007·Journal of Immunological Methods·Annette PlüddemannLeanne Peiser

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