The Class I HDAC inhibitor RGFP963 enhances consolidation of cued fear extinction

Learning & Memory
Mallory E BowersKerry J Ressler

Abstract

Evidence indicates that broad, nonspecific histone deacetylase (HDAC) inhibition enhances learning and memory, however, the contribution of the various HDACs to specific forms of learning is incompletely understood. Here, we show that the Class I HDAC inhibitor, RGFP963, enhances consolidation of cued fear extinction. However, RGFP966, a strong inhibitor of HDAC3, does not significantly enhance consolidation of cued fear extinction. These data extend previous evidence that demonstrate the Class I HDACs play a role in the consolidation of long-term memory, suggesting that HDAC1 and/or HDAC2, but less likely HDAC3, may function as negative regulators of extinction retention. The development of specific HDAC inhibitors, such as RGFP963, will further illuminate the role of specific HDACs in various types of learning and memory. Moreover, HDAC inhibitors that enhance cued fear extinction may show translational promise for the treatment of fear-related disorders, including post-traumatic stress disorder (PTSD).

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Citations

Jun 25, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Stephen Maren, Andrew Holmes
Apr 4, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Gavin RumbaughCourtney A Miller
Sep 11, 2016·Progress in Neuro-psychopharmacology & Biological Psychiatry·Xiaoyan QiuYuemin Li
Dec 8, 2016·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Janine L KwapisMarcelo A Wood
Jan 26, 2017·Neurobiology of Learning and Memory·Thekla J HemstedtMarcelo A Wood
Jan 18, 2017·Cellular and Molecular Neurobiology·Sarfraj Ahmad SiddiquiAnand Prakash
Mar 3, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Fangyuan CaoFrank J Dekker
May 6, 2017·Frontiers in Cellular Neuroscience·Ling-Sha JuJian-Jun Yang
Aug 19, 2017·Scientific Reports·Tomoharu KuboyamaHongyan Zou
Jan 31, 2019·Nature Reviews. Neuroscience·Rianne R Campbell, Marcelo A Wood
Sep 25, 2020·International Journal of Molecular Sciences·Samantha D CreightonIva B Zovkic
Mar 23, 2018·Acta Pharmacologica Sinica·Meng-Yi Xu, Albert H C Wong
Nov 7, 2018·Proceedings of the National Academy of Sciences of the United States of America·Karolina J JanczuraClaes Wahlestedt
Oct 30, 2020·Current Opinion in Neurobiology·Allison M Burns, Johannes Gräff
Aug 5, 2017·Journal of Medicinal Chemistry·Erika BourguetMickaël Naassila

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