The classification of vitreous seeds in retinoblastoma and response to intravitreal melphalan

Ophthalmology
Jasmine H FrancisFrancis L Munier

Abstract

To evaluate the clinical characteristics of the 3 classifications of vitreous seeds in retinoblastoma-dust (class 1), spheres (class 2), and clouds (class 3)-and their responses to intravitreal melphalan. Retrospective, bi-institutional cohort study. A total of 87 patient eyes received 475 intravitreal injections of melphalan (median dose, 30 μg) given weekly, a median of 5 times (range, 1-12 times). At presentation, the vitreous seeds were classified into 3 groups: dust, spheres, and clouds. Indirect ophthalmoscopy, fundus photography, ultrasonography, and ultrasonic biomicroscopy were used to evaluate clinical response to weekly intravitreal melphalan injections and time to regression of vitreous seeds. Kaplan-Meier estimates of time to regression and ocular survival, patient survival, and event-free survival (EFS) were calculated and then compared using the Mantel-Cox test of curve. Time to regression of vitreous seeds, patient survival, ocular survival, and EFS. The difference in time to regression was significantly different for the 3 seed classes (P < 0.0001): the median time to regression was 0.6, 1.7, and 7.7 months for dust, spheres, and clouds, respectively. Eyes with dust received significantly fewer injections and a...Continue Reading

References

Aug 1, 1982·Archives of Ophthalmology·D H AbramsonF D Kitchin
Mar 15, 2005·Ophthalmology Clinics of North America·A Linn Murphree
Nov 5, 2011·The British Journal of Ophthalmology·David H AbramsonY Pierre Gobin
Jun 15, 2012·The British Journal of Ophthalmology·Francis L MunierMaja Beck-Popovic
Oct 15, 2013·Acta Ophthalmologica·Katarina BartumaCharlotta All-Ericsson
Jun 21, 2014·The Open Ophthalmology Journal·Jasmine H FrancisDavid H Abramson

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Citations

Mar 16, 2016·Journal of Ophthalmology·Xunda JiPeiquan Zhao
Jan 1, 2015·Nature Reviews. Disease Primers·Helen DimarasBrenda L Gallie
Sep 13, 2016·Retina·Paula SchaiquevichDavid H Abramson
Jan 18, 2017·Ophthalmic Genetics·David H AbramsonY Pierre Gobin
Jan 11, 2017·British Medical Bulletin·Marina VasalakiMandeep S Sagoo
Jan 17, 2017·Journal of Pediatric Ophthalmology and Strabismus·Matthew D KarlDavid H Abramson
Jun 25, 2017·Pediatric Blood & Cancer·Jesse L BerryJonathan W Kim
Nov 2, 2017·The British Journal of Ophthalmology·Ursula WinterPaula Schaiquevich
Aug 28, 2017·The British Journal of Ophthalmology·Raksha RaoVijay Anand P Reddy
Jun 18, 2017·Indian Journal of Pediatrics·Raksha Rao, Santosh G Honavar
Feb 12, 2017·The British Journal of Ophthalmology·Ido Didi FabianFrancis L Munier
Apr 24, 2018·Journal of Pediatric Hematology/oncology·Eun Hye JungYoung Suk Yu
Jan 10, 2018·Journal of Neuroscience Research·Helen Dimaras, Timothy W Corson
May 31, 2017·Asia-Pacific Journal of Ophthalmology·Nathalie CassouxLaurence Desjardins
Jul 23, 2019·Journal of Binocular Vision and Ocular Motility·Jill Anderson
Jul 16, 2020·The British Journal of Ophthalmology·Jennifer NadelmannDavid H Abramson
Jan 21, 2017·European Journal of Ophthalmology·Hayyam KiratliCanan Akyüz
Jan 20, 2016·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Emiliano BuitragoPaula Schaiquevich
Mar 26, 2019·International Ophthalmology Clinics·Jesse L BerryJonathan W Kim
Mar 4, 2020·Cell Death Discovery·Arthur AubryRod Bremner
Mar 6, 2019·International Journal of Molecular Sciences·Ursula WinterPaula Schaiquevich
Nov 30, 2016·International Ophthalmology Clinics·Shuai YuanAnthony B Daniels
Jan 17, 2021·Experimental Eye Research·Elham DelrishRassoul Dinarvand
Feb 16, 2021·Clinics in Perinatology·Frank Y Lin, Murali M Chintagumpala
Feb 25, 2021·Pediatric Blood & Cancer·Jesse L BerryA Linn Murphree
Jan 20, 2021·Cell Death Discovery·Arthur AubryRod Bremner
Apr 6, 2021·Pediatric Blood & Cancer·Samir PatelMatthew J Krasin
Jul 30, 2021·Frontiers in Pharmacology·Yacoub A YousefIbrahim Al-Nawaiseh
Jun 30, 2021·Clinical & Experimental Ophthalmology·Swathi Kaliki

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