PMID: 1794109Oct 1, 1991Paper

The clastogenic effect of pyrimethamine (Daraprim) on human chromosomes in lymphocyte cultures

Cell Biology and Toxicology
U Egeli, G Erdogan

Abstract

In this study the clastogenic effect of pyrimethamine (Daraprim), a folic acid antagonist used for the treatment of toxoplasmosis and malaria on human chromosomes, was investigated. Pyrimethamine was added to in vitro lymphocyte cultures at six different concentrations: 0.05 (normal therapeutic dose), 0.1, 0.2, 0.4, 0.8, and 1.6 mg/ml. No proliferation was observed in any of the cultures containing 1.6 mg/ml pyrimethamine. The results of the cytogenetic evaluations show that the frequency of breaks and gaps increase significantly in dose-dependent manner. Thus, pyrimethamine has a clastogenic effect on human chromosomes.

References

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Citations

Feb 19, 2000·Teratogenesis, Carcinogenesis, and Mutagenesis·K K Vijayalaxmi, M Vishalakshi
Sep 5, 2002·Teratogenesis, Carcinogenesis, and Mutagenesis·Ciĝdem EgelNilüfer Aydemir
Oct 24, 2002·Teratogenesis, Carcinogenesis, and Mutagenesis·B TuncaR Bilaloglu
Feb 3, 2005·Cell Biology and Toxicology·A Abou-Eisha, M Afifi
Mar 10, 1998·Journal of Photochemistry and Photobiology. B, Biology·J D Spikes
Sep 1, 1997·Environmental Toxicology and Pharmacology·T OnoT Ohta
May 14, 2003·Mutation Research·Nilüfer Aydemir, Rahmi Bilaloğlu
Mar 11, 2008·Mutagenesis·Raffaella CorviPhilippe Vanparys
May 6, 2003·Toxicological Sciences : an Official Journal of the Society of Toxicology·Karol L Thompson, Frank D Sistare
Aug 31, 2010·Virus Research·Raphael M OguaririTomozumi Imamichi

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