The Claustrum in Relation to Seizures and Electrical Stimulation

Frontiers in Neuroanatomy
Lalitha KuradaMohamad Z Koubeissi

Abstract

The neural mechanisms of altered consciousness that accompanies most epileptic seizures are not known. We have reported alteration of consciousness resulting from electrical stimulation of the claustrum via a depth electrode in a woman with refractory focal epilepsy. Additionally, there are reports that suggest possible claustral involvement in focal epilepsy, including MRI findings of bilaterally increased T2 signal intensity in patients with status epilepticus (SE). Although its cytoarchitecture and connectivity have been studied extensively, the precise role of the claustrum in consciousness processing, and, thus, its contribution to the semiology of dyscognitive seizures are still elusive. To investigate the role of the claustrum in rats, we studied the effect of high-frequency stimulation (HFS) of the claustrum on performance in the operant chamber. We also studied the inter-claustral and the claustro-hippocampal connectivity through cerebro-cerebral evoked potentials (CCEPs), and investigated the involvement of the claustrum in kainate (KA)-induced seizures. We found that HFS of the claustrum decreased the performance in the operant task in a manner that was proportional to the current intensity used. In this article, we ...Continue Reading

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Citations

Mar 7, 2020·Current Opinion in Neurology·Isabelle Lambert, Fabrice Bartolomei
Jul 6, 2019·Frontiers in Neuroanatomy·Jared B SmithKevin D Alloway
Dec 13, 2019·Frontiers in Neuroanatomy·Christine IbrahimLeon French
Jul 16, 2019·Journal of Molecular Histology·Dimka Hinova-PalovaAdrian Paloff
Jan 27, 2021·BMJ Case Reports·Debaleena MukherjeeAlak Pandit
Nov 28, 2020·Neuroscience·Jesús Avila, George Perry
Jul 9, 2021·Behavioral and Brain Functions : BBF·Vladimir N NikolenkoGjumrakch Aliev

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