PMID: 22333130Feb 16, 2012Paper

The clinical analysis of primary central nervous system lymphoma in 23 patients

Zhonghua nei ke za zhi
Ying-zhe PiaoWen-liang Li

Abstract

To explore the clinical characteristics and the relationship between rational therapy and prognosis in primary central nervous system lymphoma (PCNSL). Clinical data of 23 patients pathologically confirmed as PCNSL and treated in our hospital from January 2005 to December 2007 were collected and analyzed retrospectively. SPSS 13.0 statistical analysis software was used to analyze the correlation between therapy, clinical characteristics and prognosis. Among the 23 patient, 10 were male and 13 were female, with a median age of 50 (2 - 75) years old. Eighteen patients were undertaken lumbar puncture, and tumor cells in cerebral spinal fluid (CSF) was found in 4 patients. Tumorectomy was performed in 8 patient, while 15 patients biopsy. Among them, 4 accepted whole brain irradiation, 6 accepted associated chemotherapy based on a high-dose of methotrexate (MTX) and 13 accepted radiotherapy combined with chemotherapy. Kaplan-Meier analysis showed that in this serial patients, the median survival time was 45.0 months and the 3-year survival rate was 56.5%. Log-Rank test revealed that the whole survival time and the non-progression survival time of radiotherapy combined with chemotherapy (43.8 and 30.0 months, respectively) and high-d...Continue Reading

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