PMID: 8311533Dec 1, 1993

The clinical and laboratory course of polymyalgia rheumatica/giant cell arteritis after the first two months of treatment

Annals of the Rheumatic Diseases
V Kyle, Brian Hazleman


To examine the clinical course of polymyalgia rheumatica (PMR) and giant cell arteritis (GCA) in a prospective study, after the initial two months. Seventy four patients with PMR/GCA were followed for a median of 60 weeks. Detailed clinical and laboratory records were made on each visit. Twenty per cent of patients with PMR developed GCA and 24% of patients with GCA developed PMR from the onset of symptoms. After two months, most patients experienced at least one relapse. Relapses and persistence of abnormal symptoms and signs were most common in patients with both PMR and GCA and least common in those with GCA alone. Relapses were most common in the first year and 54% occurred in association with steroid reduction. Major complications were rare. Laboratory parameters and temporal artery histology were not helpful in predicting relapse. Only 24% of patients were able to stop steroid treatment after two years. Clinicians should consider more frequent review in patients at times of steroid reduction and especially within the first six months of treatment.


Dec 20, 2002·The New England Journal of Medicine·Andrew J K Ostor, Brian Hazleman
Aug 9, 2008·Family Practice·Kevin BarracloughWilliam Hamilton
Feb 19, 2008·Current Opinion in Rheumatology·Nicolò Pipitone, Carlo Salvarani
Nov 26, 2010·Annals of the Rheumatic Diseases·Christian DejacoInternational Work Group for PMR and GCA
Apr 9, 2008·BMJ : British Medical Journal·Clement J Michet, Eric L Matteson
Jan 31, 2006·Journal of Clinical Pathology·W S SmellieC A Bloxham
Sep 19, 2003·Postgraduate Medical Journal·J M Calvo-Romero
Oct 17, 2006·Musculoskeletal Care·Sheena L Hennell
Jun 3, 2015·Rheumatology International·Michael SchirmerEric L Matteson
Sep 6, 2005·Survey of Ophthalmology·Waheeda Rahman, Farooq Z Rahman
Apr 29, 2005·Best Practice & Research. Clinical Rheumatology·Nicolò PipitoneCarlo Salvarani
Apr 13, 2013·European Journal of Internal Medicine·Nicolò Pipitone, Carlo Salvarani
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Sep 10, 2014·Scottish Medical Journal·Patrick J RooneyPeter Balint
Oct 10, 2001·Springer Seminars in Immunopathology·C A Stegeman, C G Kallenberg
May 27, 2020·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·María L de la TorreCecilia N Pisoni
Aug 22, 2019·Rheumatology Advances in Practice·Chetan MukhtyarColin Jones
Dec 14, 2011·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Marco A AlbaLuis Felipe Flores-Suárez
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Apr 7, 2010·Expert Opinion on Pharmacotherapy·Miguel A Gonzalez-GayRicardo Blanco
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Related Concepts

Histology Procedure
Polymyalgia Rheumatica
Rhizomelic Pseudopolyarthritis
Juvenile Temporal Arteritis
Signs and Symptoms
Giant Cell Arteritis

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