The clinical and laboratory features of neurosyphilis in HIV-infected patients: A retrospective study in 92 patients

Medicine
Zhenyan WangHongzhou Lu

Abstract

Neurosyphilis (NS) is an important component of central nervous system diseases among HIV-infected patients. However, its characteristics are not very clear. A retrospective analysis of clinical and laboratory findings was performed in 92 NS patients with HIV infection from a tertiary hospital in Shanghai, China. The patients had a median age of 38 years and a median CD4 count of 198 cells/μL. In all, 44.6% (41/92) were diagnosed as asymptomatic NS (ANS), 23.9% (22/92) as syphilitic meningitis, 17.4% (16/92) as cerebrovascular NS, and 14.1% (13/92) as parenchymal syphilis. A quarter of patients (23/92) complicated with ocular syphilis (OS), 60.9% (14/23) of which were ANS. The serum tolulized red unheated serum test (TRUST) titers were ≤1:8 in 15 patients (16.3%), 1:16-1:128 in 51 patients (55.4%), and ≥1:256 in 26 patients (28.3%). Sixty-nine patients (75.0%) had both cerebrospinal fluid (CSF) TRUST and Treponema pallidum particle assay reactive. CSF pleocytosis and protein elevation were found in 58.7% and 53.3% of patients, respectively. Syphilitic meningitis was more likely to present with CSF pleocytosis than ANS (P = .001), cerebrovascular NS (P < .001), and parenchymal NS (P < .001). The proportion of patients with CSF e...Continue Reading

References

Jan 28, 2004·The Journal of Infectious Diseases·Christina M MarraScott H Barnett
Jan 11, 2005·Current HIV Research·Derek J Chan
Jul 26, 2006·Sexually Transmitted Diseases·Agnès LiboisNathan Clumeck
Dec 13, 2006·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Rosario PalaciosJesús Santos
Apr 5, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Nicola M Zetola, Jeffrey D Klausner
Jun 6, 2008·AIDS·Khalil G GhanemKelly A Gebo
Oct 31, 2008·Sexually Transmitted Diseases·Judith BrangerJan M Prins
Feb 4, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Khalil G GhanemKelly A Gebo
Sep 22, 2009·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Lívia Leite Góes GitaíOsvaldo Massaiti Takayanagui
Aug 28, 2010·Sexually Transmitted Infections·Joseph D TuckerDonna Felsenstein
Apr 10, 2012·Journal of the Neurological Sciences·Li-Li LiuTian-Ci Yang
Jun 16, 2012·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Yi-Jen WangJen-Hsian Wang
Jan 7, 2014·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Yi-Hsin ChangChih-Yin Lew-Ting
Dec 17, 2014·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Yen-Chin ChenNai-Ying Ko
Aug 25, 2015·Journal of Ophthalmic Inflammation and Infection·Sun Young LeeNarsing Rao

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Citations

Nov 28, 2019·Experimental and Therapeutic Medicine·Cao LiGuang-Xiang Chen
Oct 28, 2019·Ocular Immunology and Inflammation·M BazewiczF Willermain
Aug 1, 2021·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Caifeng HeHong Sang

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay

Software Mentioned

SPSS

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