The Clinical and Molecular Characterization of Gastric Cancer Patients in Qinghai-Tibetan Plateau

Frontiers in Oncology
Guanghong RongYongcui Wang

Abstract

Gastric cancer was the fifth most common malignancy and the third deadliest cancer (738,000 deaths in 2018) in the world. The analysis of its molecular characteristics has been complicated by histological and intratumor heterogeneity. Furthermore, the previous studies indicate that the incidence of gastric cancer shows wide geographical variation. As the largest and highest region in China, Qinghai-Tibetan Plateau (QTP) is one of the important global biodiversity hotspots. Here, to better understand the mechanism of gastric cancer and offer the targeted therapeutic strategies specially designed for patients in QTP, we collect tumor and blood samples from 30 primary gastric adenocarcinoma cancer patients at Qinghai Provincial People's Hospital. We discuss the clinical and molecular characteristics for these patients that have been ascribed to the unique features in this place, including high altitude (the average height above sea level is around 4,000 m), multi-ethnic groups, and the specific ways of life or habits (such as eating too much beef and mutton, have alcohol and cigarette problem, et al.). By comparing with the western gastric cancer patients collected from TCGA data portal, some unique characteristics for patients in...Continue Reading

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Citations

Mar 27, 2021·Respiratory Physiology & Neurobiology·Walter S Calderón-Gerstein, Gabriela Torres-Samaniego

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Methods Mentioned

BETA
exome sequencing

Software Mentioned

COSMIC
LibSVM
SAMtools
MuttSig2
MUFFINN
gliomaScan
MaxMIF
bedtools
Burrows Aligner ( BWA )
h2o

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