The clinical and molecular epidemiology of pre-transplant vancomycin-resistant enterococci colonization among liver transplant recipients

Clinical Transplantation
David B BanachLouise M Dembry

Abstract

Vancomycin-resistant enterococci (VRE) infections cause significant morbidity in liver transplant recipients. The epidemiology and impact of pre-transplant colonization with VRE among patients who undergo liver transplantation are poorly understood. We conducted an observational cohort study to identify risk factors and outcomes associated with pre-transplant VRE colonization and described the molecular diversity among VRE strains colonizing patients who undergo liver transplantation. Perirectal VRE surveillance cultures were performed prior to transplantation. Repetitive sequence-based polymerase chain reaction (rep-PCR) testing was used to identify clonality among VRE isolates. Of 61 patients who underwent pre-transplant VRE surveillance and subsequent liver transplantation, 27 (44%) were colonized with VRE. In multivariate analysis, pre-transplant VRE colonization was associated with central venous catheterization (OR 9.4, 95% confidence interval [CI]= 1.3-70.2, p = 0.03) and rifaximin use (OR 15.4, 95% CI 1.5-159.7, p = 0.02). Pre-transplant VRE colonization was associated with more hospital days post-transplant (26.6 vs. 16.1 d, p = 0.04). Of VRE-colonized patients analyzed with rep-PCR, 68% were colonized with the same st...Continue Reading

References

Oct 1, 1996·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·G A PapanicolaouC Miller
Oct 1, 1996·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·N G TornieporthL W Riley
Dec 12, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·E M D'AgataW Schaffner
Jan 11, 2001·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·R PatelR L Thompson
Jul 27, 2002·Emerging Infectious Diseases·Yehuda CarmeliMatthew H Samore
Jun 20, 2003·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Elisabeth A HagenEmily A Blumberg
Sep 16, 2005·Transplant International : Official Journal of the European Society for Organ Transplantation·Eriak Ferraz de GouveaGuilherme Santoro-Lopes
Nov 30, 2005·Clinical Transplantation·Michelle GearhartJoseph F Buell
Dec 16, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Shelly A McNeilCarol A Kauffman
Aug 23, 2006·BMC Infectious Diseases·Maria Cecília S FreitasLuis Fernando A Camargo
Jun 19, 2008·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·D L RussellD A Pegues
Apr 26, 2011·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·N G AlmyroudisB H Segal
Jan 19, 2013·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Dale W BratzlerUNKNOWN Society for Healthcare Epidemiology of America
Mar 7, 2013·Surgical Infections·Dale W BratzlerUNKNOWN Society for Healthcare Epidemiology of America (SHEA)
Jul 22, 2014·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·P D ZiakasE Mylonakis

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Citations

Sep 24, 2016·Infectious Disease Clinics of North America·Katherine ReyesMarcus Zervos
May 27, 2016·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Jonathan Hand, Gopi Patel
Feb 11, 2018·Transplant Infectious Disease : an Official Journal of the Transplantation Society·J D LewisC D Sifri
Mar 28, 2020·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Sajed SarwarMarwan M Azar
May 26, 2017·Transplant International : Official Journal of the European Society for Organ Transplantation·Jacques SimkinsLilian M Abbo
Feb 23, 2021·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Nora CheaShelley S Magill
Mar 6, 2021·Experimental and Clinical Transplantation : Official Journal of the Middle East Society for Organ Transplantation·Fardad EjtehadiSeyed Ali Malekhosseini

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