The clinical and morphologic features of nonepidermolytic ichthyosis in the golden retriever.

Veterinary Pathology
E A MauldinM L Casal

Abstract

A scaling disorder specific to Golden Retriever dogs has been recognized by both dermatologists and pathologists, but to date has not been well characterized. At the University of Pennsylvania's Laboratory of Toxicology and Pathology, 46 cases of ichthyosis were diagnosed histologically in Golden Retriever dogs from January 2004 to January 2007. A total of 22 dogs had skin lesions documented at younger than 1 year of age; 3 dogs between 1 and 2 years of age; 13 dogs developed lesions at older than 2 years; and the time of onset was unknown for 8 dogs. A total of 25 dogs were female, and 21 were male. All dogs had strikingly similar histopathologic changes that consisted of mild to moderate laminar orthokeratotic hyperkeratosis with an absence of epidermal hyperplasia and dermal inflammation. Ultrastructural analysis using a ruthenium tetroxide fixation method was performed on punch biopsy samples from 5 dogs and compared with 2 control dogs (1 clinically and histologically normal sibling of an affected dog and 1 Cairn Terrier). All affected dogs had retained and convoluted membranes with crystalline structures in the stratum corneum. Scattered keratinocytes in the granular cell layer had prominent, clear, membrane-bound, cytopl...Continue Reading

References

Jan 1, 1985·The British Veterinary Journal·J R Baker, W R Ward
Jan 7, 1998·The Journal of Heredity·M L CasalD F Patterson
Sep 12, 1998·The Journal of Investigative Dermatology. Symposium Proceedings·P M EliasG K Menon
Jul 28, 2001·Cytogenetics and Cell Genetics·K M CredilleR W Dunstan
Jan 30, 2003·American Journal of Clinical Dermatology·John J DiGiovanna, Leslie Robinson-Bostom
Jun 5, 2003·Clinical and Experimental Dermatology·M AkiyamaH Shimizu
Aug 14, 2003·Human Molecular Genetics·Caroline LefévreJudith Fischer
Apr 1, 2004·Journal of Comparative Pathology·K F BarnhartR W Dunstan

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Citations

May 6, 2009·The Journal of Small Animal Practice·E GuaguereC André
Jul 17, 2015·Veterinary Dermatology·Anja RoethigNina Thom
Aug 6, 2015·Veterinary Pathology·A HoffmannM Hewicker-Trautwein
May 9, 2018·Veterinary Sciences·Lisa GrazianoLuisa Cornegliani
Nov 19, 2021·G3 : Genes - Genomes - Genetics·Sarah KienerTosso Leeb

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Methods Mentioned

BETA
biopsy
electron microscopy
light microscopy

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