PMID: 9537940Dec 16, 1998Paper

The clinical behavior of localized and multicentric Castleman disease

Annals of Internal Medicine
J HerradaW Pugh

Abstract

Castleman disease, an unusual condition of unknown cause consisting of a massive proliferation of lymphoid tissue, remains a clinicopathologic diagnosis. Three histologic variants (hyaline vascular, plasma-cell, and mixed) and two clinical types (localized and multicentric) of Castleman disease have been described. To analyze the clinical features, management, and outcome of patients with Castleman disease. Case series. University referral hospitals. All patients with Castleman disease who were seen at Texas Medical Center, Houston, Texas, between 1977 and 1995. Surgical excision for localized disease; surgery, combination chemotherapy, or prednisone for multicentric disease. Patients were identified according to initial presentation as having localized or multicentric Castleman disease. Patients within each group were further subdivided according to whether they had hyaline vascular, plasma-cell, or mixed disease. Data from 15 patients were analyzed. All 7 patients with localized disease underwent surgical excision and remain free of disease. The 8 patients with multicentric disease were further subdivided according to initial treatment: Three patients who received combination chemotherapy are currently alive and free of disea...Continue Reading

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