PMID: 15220696Jun 29, 2004Paper

The clinical benefits of tenofovir for simian immunodeficiency virus-infected macaques are larger than predicted by its effects on standard viral and immunologic parameters

Journal of Acquired Immune Deficiency Syndromes : JAIDS
Koen K A Van RompayM L Marthas

Abstract

Previous studies have demonstrated that tenofovir (9-[2-(phosphonomethoxy)propyl]adenine; PMPA) treatment is usually very effective in suppressing viremia in macaques infected with simian immunodeficiency virus (SIV). The present study focuses on a subset of infant macaques that were chronically infected with highly virulent SIVmac251, and for which prolonged tenofovir treatment failed to significantly suppress viral RNA levels in plasma despite the presence of tenofovirsusceptible virus at the onset of therapy. While untreated animals with similarly high viremia developed fatal immunodeficiency within 3-6 months, these tenofovir-treated animals had significantly improved survival (up to 3.5 years). This clinical benefit occurred even in animals for which tenofovir had little or no effect on CD4 and CD8 lymphocyte counts and antibody responses to SIV and test antigens. Thus, the clinical benefits of tenofovir were larger than predicted by plasma viral RNA levels and other routine laboratory parameters.

References

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Citations

Nov 4, 2010·AIDS Research and Human Retroviruses·Jean-Louis ExclerPatricia Fast
Sep 10, 2011·AIDS Research and Human Retroviruses·Koen K A Van Rompay
Mar 8, 2005·Journal of Clinical Microbiology·Jan WeberMiguel E Quiñones-Mateu
Sep 16, 2006·Journal of Virology·Graciela AndreiDavid H Evans
Apr 29, 2004·Journal of Virology·Koen K A Van RompayNorbert Bischofberger
May 23, 2017·Lab Animal·Koen K A Van Rompay
Sep 18, 2010·Current Opinion in Infectious Diseases·David A M C van de Vijver, Charles A B Boucher
Sep 5, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ruth H FloreseMarjorie Robert-Guroff
Jul 23, 2009·Antiviral Research·Koen K A Van Rompay

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