The clinical determinants of malignant transformation in oral epithelial dysplasia

Oral Oncology
M W HoRichard J Shaw

Abstract

While the size and clinical appearance are known risk factors for malignant transformation of potentially malignant oral the importance of site, grade of dysplasia and exposure to environmental carcinogens remains controversial. We aim to report the clinical determinants of malignant progression in a series of patients with histopathologically graded oral epithelial dysplasia (OED). We recruited patients with a histopathological diagnosis of OED to a longitudinal observational study in a tertiary oral dysplasia clinic. Clinical, histopathological and risk factor data were recorded at baseline. One of three clinical endpoints were determined: malignant transformation, progression of dysplasia grade, remission/stable dysplasia grade. Ninety-one patients meeting the criteria gave consent for inclusion to the cohort, with outcomes reported after a median follow up of 48 months. An estimated 22% (SE 6%) of patients underwent malignant transformation within 5 years, with significant predictors being: non-smoking status (χ(2)=15.1, p=0.001), site (χ(2)=15.3, p=0.002), non-homogeneous appearance (χ(2)=8.2, p=0.004), size of lesion >200 mm(2) (χ(2)=4.7, p=0.03) and, of borderline significance, high grade (χ(2)=5.8, p=0.06). Gender, age,...Continue Reading

References

Jun 1, 1979·Journal of Oral Pathology·M A Pogrel
Mar 21, 1978·British Dental Journal·I R KramerK W Lee
Feb 1, 1996·The British Journal of Oral & Maxillofacial Surgery·J J MarleyK A Warnakulasuriya
Feb 12, 1998·Oral Oncology·I van der WaalL E Smeele
Dec 1, 2005·Oral Oncology·P HolmstrupK Stoltze
Jan 30, 2007·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Michael BrennanIsaäc van der Waal
Apr 24, 2007·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Robert J CabayJoel B Epstein
Aug 19, 2008·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Gillian L HallJanet M Risk
May 21, 2009·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Paolo G ArduinoRoberto Broccoletti
May 21, 2009·Head & Neck·Hisham M MehannaChristopher C McConkey
Sep 25, 2009·Human Molecular Genetics·Nilva K CervigneSuzanne Kamel-Reid
Oct 6, 2009·The British Journal of Oral & Maxillofacial Surgery·O HamadahP J Thomson
Oct 13, 2011·Journal of Dental Research·C F PohM P Rosin

❮ Previous
Next ❯

Citations

Jun 8, 2013·International Journal of Oral Science·Diana V Messadi
Aug 13, 2013·International Journal of Dentistry·A DiajilP J Thomson
Oct 10, 2014·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·M Pérez-SayánsA García-García
Nov 20, 2012·The British Journal of Oral & Maxillofacial Surgery·Anand KumarPeter A Brennan
Sep 28, 2015·Oral Oncology·Yuri KuribayashiHiroyuki Harada
Oct 15, 2013·International Journal of Cancer. Journal International Du Cancer·Jatinder KaurRanju Ralhan
Jan 1, 2014·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Paul NankivellHisham Mehanna
Jun 23, 2015·The Journal of Pathology·Henry M WoodPamela Rabbitts
Jan 7, 2014·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·F DostC S Farah
Jul 23, 2015·Oral Oncology·E A FieldR J Shaw
Jul 21, 2015·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·S Warnakulasuriya, A Ariyawardana
Jul 29, 2015·CA: a Cancer Journal for Clinicians·Angela C ChiBrad W Neville
Dec 26, 2012·Oral Oncology·Peter Meisel, Thomas Kocher
Oct 11, 2016·Journal of Oral and Maxillofacial Pathology : JOMFP·T V Narayan, S Shilpashree
May 25, 2016·Australian Dental Journal·M Granero Fernandez, P Lopez-Jornet
Apr 14, 2016·British Journal of Hospital Medicine·Anne M Hegarty, Keith D Hunter
May 13, 2018·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·P J Thomson
Jun 26, 2018·Oral Diseases·Suelen Teixeira LuizAline Cristina Batista Rodrigues Johann
Jun 1, 2018·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Meri SieviläinenAhmed Al-Samadi
Jun 7, 2019·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Kate ShearstonCamile S Farah
Jun 7, 2019·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Xin Min AngCamile S Farah
Oct 2, 2020·The Journal of Pathology. Clinical Research·Aiman AliMarco Magalhaes
Mar 20, 2019·Head and Neck Pathology·Sook-Bin Woo
May 16, 2019·Periodontology 2000·Wanninayake M TilakaratneRohana Kumara De Silva
May 22, 2020·Clinical Oral Investigations·Primali Rukmal JayasooriyaSaman Warnakulasuriya
Feb 25, 2014·Expert Review of Anticancer Therapy·Aru PanwarAaron Wieland
Jan 9, 2014·Expert Review of Anticancer Therapy·Aru PanwarAaron Wieland
Jan 16, 2021·Oral Diseases·Camile S Farah
Sep 7, 2017·The Journal of Contemporary Dental Practice·Vivian GallettaDante Migliari
May 20, 2021·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Qianming ChenXin Zeng
Jul 26, 2021·The British Journal of Oral & Maxillofacial Surgery·P M HankinsonS A Khurram
Aug 8, 2021·Cancers·Caroline McCarthyRichard J Shaw
Dec 1, 2020·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Pranab Kumar SahooVilas D Nasare

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Candida albicans

Candida albicans is an opportunistic, fungal pathogen of humans that frequently causes superficial infections of oral and vaginal mucosal surfaces of debilitated and susceptible individuals. Discover the latest research on Candida albicans here.

Related Papers

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Fatima DostCamile S Farah
Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
Paolo G ArduinoRoberto Broccoletti
Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
S WarnakulasuriyaH Møller
© 2021 Meta ULC. All rights reserved